Our website does not fully support your browser.

We've detected that you are using an older version of Internet Explorer. Your commerce experience may be limited. Please update your browser to Internet Explorer 11 or above.

Promega's Cookie Policy

We use cookies and similar technologies to make our website work, run analytics, improve our website, and show you personalized content and advertising. Some of these cookies are essential for our website to work. For others, we won’t set them unless you accept them. To find out more about cookies and how to manage cookies, read our Cookie Policy.

Mass Spectrometry

Proteins are generally digested with proteases to generate peptides for mass spectrometry analysis (e.g., bottom-up proteomics). Promega provides high-quality proteases, including trypsin and alternative proteases specifically developed for mass spectrometry applications. For middle-down proteomics of antibodies, we offer IdeS/IdeZ proteases. We also offer glycosidases for use in analysis of post-translational modifications, as well as peptide reference mixes and other reagents for monitoring mass spectrometry instrument performance.

Introduction to Mass Spectrometry

Mass spectrometry (MS) is a powerful analytical tool used for proteome-wide analysis and characterization of proteins from a variety of organisms and cell types. MS is a sensitive method for detecting molecules based on their mass-to-charge ratio. Recent advances in mass spectrometry provide tools for protein identification, protein characterization, relative and absolute quantitation, and the study of post-translational modifications and protein:protein interactions.

Mass spectrometry products available from Promega are used for many proteomics research and drug development applications, including identification and characterization of biotherapeutic antibodies and evaluation of post-translational modifications that may affect antibody efficacy or stability.