Nucleic Acid Extraction
Promega nucleic acid extraction chemistries cover a full range of sample throughput needs--from single-prep manual solutions through benchtop automation to plate-based systems compatible with robotic liquid handlers.
Here, you’ll find a range of nucleic acid extraction products that generate high yields of high-quality genomic DNA, plasmid DNA, RNA or total nucleic acid from many sample types. We also provide products for clean up and concentration of DNA or RNA from dilute solutions, gel slices or PCR.
Nucleic Acid Extraction Product Groups
Kits to isolate genomic DNA from blood, cells, tissues and more. A variety of processing formats to suit your extraction needs.
Viral RNA and DNA Extraction
Maxwell® RSC 48 Instruments and Viral TNA Purification Kit are approved RNA extraction options in CDC COVID-19 EUA Diagnostic Panel.
Reagents for extraction of total RNA and miRNA from blood, cells, tissues, plants and other sample types.
Plasmid prep kits in miniprep, midiprep or maxiprep format.
DNA/RNA Clean-up and Concentration
Flexible options to purify and concentrate DNA fragments from PCR or gels.
DNA and RNA Quantitation
Sensitive, accurate systems for quantifying extracted DNA or RNA.
Top Nucleic Acid Extraction Products for Your Lab
Maxwell® RSC Blood DNA Kit
Purifies DNA from whole blood samples using the Maxwell® RSC Instrument.
Maxwell® RSC 48 Instrument
Benchtop instrument for automated nucleic acid purification of 1–48 samples. For Research Use Only.
ReliaPrep™ FFPE gDNA Miniprep System
Fast, manual method for purifying DNA from FFPE tissue without using organic solvents.
Nucleic Acid Extraction Basics
Extraction of DNA, RNA or total nucleic acids from samples such as blood, cultured cells, microbes or plant and animal tissues is critical to the success of many experiments. Purity and yield of the extracted nucleic acids is key to performance in downstream applications such as PCR and sequencing.
During purification, samples all progress though a common set of manipulations: cell lysis, clearing, inactivation of nucleases, nucleic acid binding, washing and elution.
Optimization of extraction methodologies is key for success, especially with challenging sample types and demanding downstream applications. The target nucleic acid should be purified free of contaminants, including proteins, other cellular components and undesired nucleic acids.
Most DNA extraction methods purify DNA away from other cellular materials by binding the DNA to a solid support such as silica or cellulose, purifying the extracted DNA away from contaminants by washing, and then eluting the purified DNA into water or buffer.