Assays to measure markers of inflammation or inflammasome activation include measurement of caspase-1 activity. The Caspase-Glo® 1 Assay provides a homogeneous, bioluminescent method to selectively measure caspase-1 activity, an essential component of the inflammasome, directly from cells or medium.
Standard methods such as Western blot analysis for detecting inflammasome activation are labor-intensive and time-consuming. They also do not measure the activity of caspase-1. The Caspase-Glo® 1 Inflammasome Assay offers a better alternative that provides easier, direct detection of caspase-1 activity in multiwell plates. The assay protocol is a simple, one-step addition that generates a stable, sensitive luminescent signal. This makes the assay ideal for multiplexing with other assays and for automated high-throughput screening applications.
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