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Small Molecule Drug Discovery

The process of small molecule drug discovery can be complex and challenging.  A typical workflow begins with hit identification and assay development, and carries through to preclinical candidate selection. High-throughput screening of drug candidates plays in essential role in the drug discovery process.

Promega offers a comprehensive selection of tools to accelerate drug discovery, based on an innovative, sensitive bioluminescence platform.

 

 

Solutions for Small Molecule Screening

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Lumit™ Immunoassays

Replace conventional immunoassays with simple, rapid and sensitive methods for direct analyte measurement.
CRISPR cas9 knock-in tagging

CRISPR/Cas9-Enabled Endogenous Biology

Explore a world of possibilities built around CRISPR/Cas9 knock-in gene editing and bioluminescence technology to study protein dynamics in live cells.
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Targeted Protein Degradation

Study small molecule-induced protein degradation in live cells.
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GPCR Research

Monitor the effect of test compounds on GPCRs and membrane receptors, study cAMP/cGMP signaling, or use a luciferase biosensor for real-time detection of signaling events.
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Target Engagement

Measure compound (small-molecule) binding at select target proteins in real time.
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Cell Health Screening Assays

Examine multiple aspects of cell health in response to small molecule drugs, using high-throughput cell viability and cytotoxicity assays.
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Energy Metabolism and Oxidative Stress

Use sensitive assays to measure metabolic activity in cells, including glucose uptake, oxidative stress and dinucleotide detection.
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ADME/Toxicity Assays

Study drug metabolism and toxicity with sensitive assays suitable for high-throughput workflows.
kinase-biology-solution

Kinase Biology

Discover biochemical assays for inhibitor screening, kinase-ligand binding assays in live cells, and request custom kinase assay services.
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Epigenetics

Choose from a range of assays and reagents for methylation analysis and protease activity.
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Microplate Readers, Fluorometers and Luminometers

Build screening assays with instruments designed for luminescence, absorbance, and fluorescence detection in an easy-to-use, modular format.
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Assay Development and Services

Take advantage of our assay development experience to streamline your drug discovery and development workflow.

Support for Contract Research Organizations (CROs)

Discover how Promega can help your CRO develop better solutions for your clients.

Learn More

NanoBRET™ Technology Powers Drug Discovery

Learn how Aurelia Bioscience used NanoBRET™ technology to measure kinase target engagement under more physiologically relevant conditions.

If you have questions or challenges with small molecule screening, we’re here to help.

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