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NanoLuc® Luciferase: Redefining Reporter Assays

Collage showing applications of NanoLuc technology

A Versatile Luciferase for BRET, Protein Interactions, Reporter Assays and More

The small size and bright luminescence of NanoLuc® Luciferase bring exquisite sensitivity to reporter assays and other bioluminescence applications.

The flexible NanoLuc® technology provides you with the building blocks to understand biological interactions at physiologically relevant levels in ways that have never been possible before.

NanoLuc® Luciferase is more sensitive than other luciferases.

A comparison of the sensitivity of NanoLuc®, firefly and Renilla luciferase assays.

A comparison of the sensitivity and brightness of NanoLuc®, firefly, and Renilla luciferase assays.

A comparison of the sensitivity of NanoLuc®, firefly and Renilla luciferase assays.

A comparison of the sensitivity and brightness of NanoLuc®, firefly, and Renilla luciferase assays.

Use the navigation below to explore the possibilities that NanoLuc® Technology brings to:

  • Protein:Protein and Protein:Ligand Interactions
  • Protein Stability
  • Genetically-encoded Biosensors
  • In vivo Imaging
  • Reporter Assays and Cell Signaling

Why the Brightness of NanoLuc Luciferase Matters

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Explore NanoLuc® Luciferase

Protein:Protein Interactions

New ways to understand protein interactions, identify the partners involved, and decipher their biological significance.

Protein:Protein Interactions
Target Engagement

Quantify the interaction between a molecule and a protein in real time, live cell assays.

Target Engagement
Biosensors

BRET-based biosensors to detect signaling events inside and outside of the cell.

Biosensors
Protein Stability

Monitor changes in intracellular protein abundance with NanoLuc® fusion proteins.

Protein Stability
Gene Regulation & Cell Signaling

Greater sensitivity and versatility for traditional gene regulation assays.

Gene Regulation & Cell Signaling
Imaging

Sensitive, bright bioluminescent imaging in cells and whole animals.

Imaging