We will be conducting our annual physical inventory from March 11th through March 13th.

Orders received after 4pm CST on Tuesday, March 10th will be scheduled to ship as follows:

US Orders: Ship Saturday, March 14th for arrival on Monday, March 16th.
Canada Orders: Ship Monday, March 16th for arrival on Tuesday, March 17th.

Select items may ship earlier. For questions regarding the status of your order, contact custserv@promega.com.

Success

Thank you for verifying your email address.

Email Verification Error

There was an issue verifying your email address. Please try again or contact Customer Service.

contact Customer Service

Mass Spectrometry

Proteins are generally digested with proteases to generate peptides for mass spectrometry analysis (e.g., bottom-up proteomics). Promega provides high-quality proteases, including trypsin and alternative proteases specifically developed for mass spectrometry applications. For middle-down proteomics of antibodies, we offer IdeS/IdeZ proteases. We also offer glycosidases for use in analysis of post-translational modifications, as well as peptide reference mixes and other reagents for monitoring mass spectrometry instrument performance.
Learn about Mass Spectrometry
Shop Mass Spectrometry products

Mass Spectrometry Product Groups

Glycosidases

Molecular tools to characterize protein glycosylation. Includes PNGase F, Endo H and Fetuin.

Reference Reagents for Mass Spectrometry

Reagents and yeast or human extracts for monitoring liquid chromatography (LC) and mass spectrometry (MS) instrument performance, and to assist in method development and optimization.

Proteases

Find high quality proteases, including trypsin and alternative proteases specifically developed for mass spec applications.

Trypsin

A choice of trypsin formulations for rapid digestion, digestion of resistant proteins, peptide mapping and peptide identification.

Protein Enrichment and Sample Cleanup

Explore magnetic bead tools for protein purification, antibody capture, and SP3-based prep with MPSP beads.

Top Mass Spectrometry Products for Your Lab

Trypsin/Lys-C Mix, Mass Spec Grade

Increased peptide recovery, enhanced protein quantitation, improved reproducibility.

V5071, V5072, V5073

AccuMAP® Low pH Resistant rLys-C Solution

A component of the AccuMAP® Low pH Protein Digestion Kit.

VA1030

rAsp-N, Mass Spec Grade

Cleavage site: N-terminal of Asp. Optimal pH: 6–9.

VA1160

Mass Spectrometry Resources

Resource

Common Shortcomings of MS Grade Trypsins and the Approaches to Address Them

Resource

Optimizing Proteomic Sample Preparation Based on Digestion Efficiency and Specificity

Resource

A Novel Trypsin for Accurate Characterization of Biotherapeutic Proteins with Peptide Mapping

Introduction to Mass Spectrometry

Mass spectrometry (MS) is a powerful analytical tool used for proteome-wide analysis and characterization of proteins from a variety of organisms and cell types. MS is a sensitive method for detecting molecules based on their mass-to-charge ratio. Recent advances in mass spectrometry provide tools for protein identification, protein characterization, relative and absolute quantitation, and the study of post-translational modifications and protein:protein interactions.

Mass spectrometry products available from Promega are used for many proteomics research and drug development applications, including identification and characterization of biotherapeutic antibodies and evaluation of post-translational modifications that may affect antibody efficacy or stability.

Related Protein Analysis Products and Resources

Categories

Related Groups

Guides and Selectors

Top Products

Let's find the product that meets your needs.

Talk to a Scientist

customer-support-global

Choose your country

Americas

Brazil
/
Canada
/
United States
/

Pacific Asia

Australia
China
India
Japan
/
Republic of Korea
/
Singapore

Europe

Austria
/
Belgium
Denmark
(Incl. Faroe Isl. & Greenland)
Estonia
Finland
(Incl. Åland)
France
/
Germany
/
Iceland
Ireland
Italy
/
Luxembourg
Netherlands
Norway
(Incl. Svalbard)
Poland
/
Portugal
/
Spain
/
Sweden
Switzerland
United Kingdom

Manage Cookies

Necessary Cookies

We use these cookies to ensure our site functions securely and properly; they are necessary for our services to function and cannot be switched off in our systems. They are usually only set in response to actions made by you which amount to a request for services, such as logging in, using a shopping cart or filling in forms. You can set your browser to block or alert you about these cookies, but some parts of our services will not work without them. Like the other cookies we use, strictly necessary cookies may be either first-party cookies or third - party cookies.

Allow Preference Cookies

We use these cookies to remember your settings and preferences. For example, we may use these cookies to remember your language preferences.

Allow Performance/Statistics Cookies

We use these cookies to collect information about how you interact with our services and to help us measure and improve them. For example, we may use these cookies to determine if you have interacted with a certain page.

Allow Marketing Cookies

We and our advertising partners use these cookies to deliver advertisements, to make them more relevant and meaningful to you, and to track the efficiency of our advertising campaigns, both on our services and on other websites and social media.

Your Privacy Choices

Our website supports your privacy choices by allowing users in select regions to opt out of specific types of sharing/sales/use of cookies and technologies for Targeted Advertising. Visit our Privacy Policy and Cookie Policy pages to learn more about these topics.

Targeted Advertising

Deselect this checkbox to disable cookies related to targeted advertising in your Promega experience. These advertising cookies will no longer be set for this browser and device.

Note: These settings are based on necessary cookies that are placed on your device, and if those cookies are cleared or you access the website from another browser or device, advertising cookies might be reset by default in the future, from which you can opt-out.