Reporter bioassays and cell health assays are used to characterize and develop novel mAb-based therapeutics. This page includes product listings and examples of how functional bioassays are used throughout biologics drug development workflows.
Bioassays are available to interrogate the following biological functions:
- Fc effector activity
- Immune checkpoint modulation
- T cell retargeting
- Cytokine and growth factor signaling
- Tumor antigen-specific cell killing
In addition to the products listed below, our Assay Development and Services team can provide personalized solutions for your workflow.
A Multipronged Approach to Antibody Therapeutics
Antibody-based therapeutic drugs can be broadly classified into six categories depending on their mechanism of action (MOA), as indicated in the schematic below. Many biologic drugs function via a single mechanism; however, newer drug candidates are being designed that function through multiple mechanisms. The use of MOA-based bioassays to measure the activity of drug candidates is critical throughout the drug development workflow.
Adapted from Weiner, et al. (2015) Nature Reviews Cancer 15, 361–70
Viral Vaccine Development
These publications highlight the use of Promega ADCC and ADCP bioassays in viral vaccine and therapeutic research and development.
Immunotherapeutic Drug Development
These publications highlight use of Promega reporter bioassays for mAb therapeutics, bispecific antibodies, and other immunotherapy applications.
Shop Functional Bioassays by Target Class or Biological Endpoint
Choosing a Bioactivity Assay
This webinar from Charles River Labs discusses their bioassay development and optimization workflow.
Bioassays Power Combination Immunotherapy
Read our GEN tutorial to learn how reporter bioassays can accelerate combination immunotherapy research.
Tips and Tools for Successful Immunotherapy Bioassay Development
In this webinar, bioassay experts discuss key considerations and answer questions about optimizing functional, MOA-based bioassays.
Measuring ADCC and CDC Activity of Anti-TNFα and Anti-VEGF Therapeutic mAbs
Learn how reporter bioassays and cell health assays are used to measure Fc effector activity.
Rapid Antibody Selection Methods for Immunotherapeutic Candidate Development
In this webinar, Single Cell Technology discusses the AbTheneum™ platform for downstream testing of candidate therapeutic antibodies.
Quantitative Cell-Based Reporter Gene Bioassays to Advance Individual or Combination Cancer Immunotherapy
This poster describes the application of MOA-based bioassays for biologics drug discovery, development, potency and stability studies.