Reporter bioassays and cell health assays are used to characterize and develop novel mAb-based therapeutics. This page includes product listings and examples of how functional bioassays are used throughout biologics drug development workflows.
Bioassays are available to interrogate the following biological functions:
- Fc effector activity
- Immune checkpoint modulation
- T cell retargeting
- Cytokine and growth factor signaling
- Tumor antigen-specific cell killing
A Multipronged Approach to Antibody Therapeutics
Antibody-based therapeutic drugs can be broadly classified into six categories depending on their mechanism of action (MOA), as indicated in the schematic below. Many biologic drugs function via a single mechanism; however, newer drug candidates are being designed that function through multiple mechanisms. The use of MOA-based bioassays to measure the activity of drug candidates is critical throughout the drug development workflow.
Adapted from Weiner, et al. (2015) Nature Reviews Cancer 15, 361–70
Shop Functional Bioassays by Target Class or Biological Endpoint
Choosing a Bioactivity Assay
This webinar from Charles River Labs discusses their bioassay development and optimization workflow.
Tips and Tools for Successful Immunotherapy Bioassay Development
In this webinar, bioassay experts discuss key considerations and answer questions about optimizing functional, MOA-based bioassays.
Bioassays Power Combination Immunotherapy
Read our GEN tutorial to learn how reporter bioassays can accelerate combination immunotherapy research.
Measuring ADCC and CDC Activity of Anti-TNFα and Anti-VEGF Therapeutic mAbs
Learn how reporter bioassays and cell health assays are used to measure Fc effector activity.
Characterizing a Novel Anti-CTLA-4 Blockade mAb
This publication describes how Agenus Bio uses immune checkpoint and ADCC bioassays to characterize a novel therapeutic mAb.
Characterizing Immune Checkpoint Blockade and Agonist mAbs using Novel Immunotherapy Bioassays
Explore our broad portfolio of reporter bioassays for measuring mAb bioactivity, potency and stability.