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High-Throughput Compound Profiling Using Tecan Instrumentation

Tracy Worzella and Brad Larson
Promega Corporation
Publication Date: 2006

Abstract

Combining high-throughput, homogeneous screening assays and integrated automated instrumentation allows researchers to efficiently profile compounds that may be potential drugs. To assess if the compounds of interest are worth pursuing, multiple assays are required to examine cell responses (e.g., apoptosis) and effects on nontarget biochemical systems such as cytochrome P450 and kinases. Knowing how the drug affects its target and becoming aware of any potential cytotoxicity and other off-target effects are essential in the drug discovery decision-making process.

Promega Notes 92, 4–6.