Our website does not fully support your browser.

We've detected that you are using an older version of Internet Explorer. Your commerce experience may be limited. Please update your browser to Internet Explorer 11 or above.

We believe this site might serve you best:

United States

United States

Language: English

Promega's Cookie Policy

Our website uses functional cookies that do not collect any personal information or track your browsing activity. When you select your country, you agree that we can place these functional cookies on your device.

Signaling Pathway Assays

Here you will find assays to detect analytes produced during enzymatic reactions involved in signaling such as ADP, AMP, UDP and GDP as well as growth factors, and phosphatase assays. Kinase assay reagents are found in the Kinase Activity Assays section. Use the filters below to find the product that meets your needs.

Save 20% on Detection Instruments to Optimize Your Assays ›

Filter By


Product Type

Shop all SIgnaling Pathway Assays

Showing 14 of 14 Products

Signaling Pathway Assay Basics

Signal transduction is one of the most widely studied areas in biology. Extracellular information perceived at the surface of a cell must be translated into an intracellular response that involves a complex network of interwoven signaling cascades. These signaling events regulate cellular responses like proliferation, differentiation, secretion and apoptosis. Signal transduction cascades are generally triggered by the binding of ligands, such as growth factors, cytokines, neurotransmitters, or hormones, to a receptor. These receptors transmit the stimulus to the interior of the cell, where the signal is amplified and directed through a signaling pathway.

A number of key reversible post-translational modifications (PTMs) occur during signal transduction- the most common being phosphorylation. Other PTMs include glycosylation, ubiquination, acetylation and methylation to name just a few. These modifications provide cells with an enormous capacity for biological diversity that allow them to regulate every aspect of cellular life (Theillet, F.X., et al. (2012) Cell signaling, post-translational protein modifications and NMR spectroscopy. J. Biomol, NMR 54(3):, 217–236).