Arg-C, Sequencing Grade, is an endopeptidase (clostripain) that cleaves at the C-terminus of arginine residues, including the sites next to proline. Cleavage can also occur at lysine residues. This sequencing grade enzyme can be used alone or in combination with other proteases for protein analysis by mass spectrometry and other applications. Arg-C activity is optimal in the pH range of 7.6–7.9.
- Peptide mapping
- Protein identification
- Characterization of post-translational modifications