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LY 294002

Potent Inhibitor of Phosphatidylinositol 3-Kinases

  • Cell-permeable
  • Specifically inhibits PI 3-kinases
  • Supplied as a dried powder

Size

Catalog number selected: V1201

$ 167.00
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LY 294002
5mg
$ 167.00
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LY 294002 [2-(4-Morpholinyl)-8-phenyl-4 H-1-benzopyran-4-one] is a potent and specific cell-permeable inhibitor of phosphatidylinositol 3-kinases (PI 3-kinases) with IC50 values in the 1–50μM range. LY 294002 competitively inhibits ATP binding to the catalytic subunit of PI 3-kinases and does not inhibit PI 4-kinase, DAG-kinase, PKC, PKA, MAPK, S6 kinase, EGFR or c-src tyrosine kinases and rabbit kidney ATPase. The chemical identity and purity of LY 294002 is confirmed by proton NMR and elemental analysis.

LY 294002 is supplied as a dried powder. Resuspend 5mg in 325μl DMSO to produce a 50mM stock solution.

References

  1. Rameh, L.E. and Cantley, L.C. (1999) J. Biol. Chem. 274, 8347–50.
  2. Fruman, D.A. et al. (1998) Annu. Rev. Biochem. 67, 481–507.
  3. Vlahos, C. et al. (1995) J. Immunol. 154, 2413–22.
  4. Vlahos, C. et al. (1994) J. Biol. Chem. 269, 5241–8.

Specifications

What's in the box?

Item Part # Size

LY 294002

V120A 1 × 5mg

SDS

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Download SDSPDF (202 KB) – English (United States)

Certificate of Analysis

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Use Restrictions

For Research Use Only. Not for Use in Diagnostic Procedures.

Storage Conditions

BB

Store at –20°C in the dark, ideally in a nonfrost-free freezer.

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