Support for CROs
Promega has partnered with over 500 contract research organizations (CROs) globally to help them serve their clients better. CROs currently use Promega assays for early-stage drug discovery, bioanalytical testing, genomic analysis and many other applications.
Why Partner with Promega?
CRO Case Study
Solutions for Small Molecule Drug Discovery
Chemoproteomic Method for On- and Off-Target Identification: This novel platform uses a photoreactive cleavable chloroalkane tag that can be attached to bioactive compounds. The tagged compounds, bound to their respective cellular targets, can then be isolated for identification by mass spectrometry.
NanoBRET™ Target Engagement Assays: Putative targets identified by mass spectrometry can be readily verified using bioluminescence resonance energy transfer (BRET). By exchanging the chloroalkane tag for a fluorophore, direct binding to the targets can be revealed through proximity of the fluorophore to a small NanoLuc® luciferase molecule, which is genetically fused to the putative target.
Accelerate your small molecule drug discovery process with a broad portfolio of high throughput-compatible biochemical and cell-based assays.
Lead Optimization and Validation
Easy to use assays provide a comprehensive assessment of cell health state in multiple model systems and sample types, including 3D microtissues, primary cells, and stem cells. Whether your target of interest is a kinase, GPCR or a disease-relevant signaling pathway, our sensitive, target-specific assays for lead compound optimization and validation can help.
Solutions for Biologics Drug Discovery and Development
Functional BioassaysReporter bioassays are used to characterize and develop novel antibody-based therapeutics. Explore our comprehensive portfolio of functional bioassays that provide a convenient, add-mix-read format applicable throughout the drug development workflow.
Bioanalytical TestingAnalytical characterization of biologic drugs is critical during all stages of the drug development workflow. Explore our bioanalytical tools for antibody purification, internalization, peptide mapping, and analysis of glycosylation and post-transcriptional modifications.
Solutions for Genomic Analysis
Nucleic Acid Extraction
Regardless of sample type, you can choose nucleic acid extraction kits that generate high yields. From single-prep manual solutions, to cartridge-based Maxwell® Systems, to plate-based processing compatible with high-throughput liquid handling systems—Promega chemistries cover the range of your purification needs.
Nucleic Acid Quantitation and Analysis
A diverse portfolio of products support your nucleic acid quantitation and analysis needs. These sensitive and accurate methods include fluorescent dyes and fluorometers, as well as qPCR and qRT-PCR kits, to provide consistent, reliable results for downstream analysis.
Bioactivity Assays: Putting the Puzzle Together
Charles River Laboratories discusses their bioassay development and optimization workflow.
Validating Cell-Based Assays for Use with 3D Culture Models
InSphero, in collaboration with Promega, presents the results from improved cell health assay protocols for 3D cultures.
Bottoms Up: Improving Proteomic Sample Preparation
A multi-enzyme workflow, developed in collaboration with Just Biotherapeutics, greatly improves sequence coverage for mass spectrometry analysis of therapeutic antibodies.