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Support for CROs

Promega partners with over 200 contract research organizations (CROs) globally to help them serve their clients better. CROs currently use Promega assays for early-stage drug discovery, bioanalytical testing, genomic analysis and many other applications.

A Broad Range of Solutions

As a CRO, your clients depend your support to guide them through the long and complex drug discovery pathway. Our assay solutions can help you deliver results, from target validation through ADME/toxicity screening. We have scientific and technical expertise in reporter bioassays, target engagement, antibody purification, bioanalytical sample preparation, and so much more. Let us guide you to developing better solutions for your clients.

 

Target Identification and Validation

Chemoproteomic Method for On- and Off-Target Identification

This novel platform uses a photoreactive cleavable chloroalkane tag that can be attached to bioactive compounds. The tagged compounds, bound to their respective cellular targets, can then be isolated for identification by mass spectrometry.

  • Modular probe design: sufficient crosslinking without customized chemistry
  • Minimal influence on cell permeability
  • Built-in capabilities for selective capture and elution—no need for biorthogonal ligation of an affinity tag
  • Selective enrichment with minimal background
  • Enrichment of soluble and insoluble targets
  • Simple and efficent protocol

Please contact us for more information about this novel platform.

Target Validation by NanoBRET™ Target Engagement Assays

Putative targets identified by mass spectrometry can be readily verified using bioluminescence resonance energy transfer (BRET). By exchanging the chloroalkane tag for a fluorophore, direct binding to the targets can be revealed through proximity of the fluorophore to a small NanoLuc® luciferase molecule, which is genetically fused to the putative target.

  • Orthogonal method for verification of putative targets identified by mass spectrometry
  • Simple and quantitative assessment of binding affinity

Learn more about NanoBRET TE assays.

 

High-Throughput Screening

Accelerate your small molecule drug discovery process with a broad portfolio of high throughput-compatible biochemical and cell-based assays.

For biologic drug discovery, development and validation, our high throughput-compatible functional bioassays offer comprehensive solutions.

 

Lead Optimization and Validation

Easy to use assays provide a comprehensive assessment of cell health state in multiple model systems and sample types, including 3D microtissues, primary cells, and stem cells. Whether your target of interest is a kinase, GPCR or a disease-relevant signaling pathway, our sensitive, target-specific assays for lead compound optimization and validation can help. Learn more about  cell health assays for drug discovery.

 

Bioanalytical Testing

Analytical characterization of biologic drugs is critical during all stages of the drug development workflow. Explore our bioanalytical tools for antibody purification, internalization, peptide mapping, and analysis of glycosylation and post-transcriptional modifications.

 

Nucleic Acid Extraction

Regardless of sample type, you can choose nucleic acid extraction kits that generate high yields. From single-prep manual solutions, to cartridge-based Maxwell® Systems, to plate-based processing compatible with high-throughput liquid handling systems—Promega chemistries cover the range of your purification needs.

 

Nucleic Acid Quantitation and Analysis

A diverse portfolio of products support your nucleic acid quantitation and analysis needs. These sensitive and accurate methods include fluorescent dyes and fluorometers, as well as qPCR and qRT-PCR kits, to provide consistent, reliable results for downstream analysis.  

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Building Partnerships

Partnering with us is easy through a variety of mechanisms. We can provide custom quotes for direct purchase and use in your business. We can also work with clients to transfer assays to a CRO. No matter what option you choose, we’ll provide a team of scientific experts to support you from start to finish...and beyond. 

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Learn more about how we can help you.

Contact Us
Energy Metabolism Webinar

Target Engagement for Drug Discovery

Learn how Aurelia Bioscience is using NanoBRET™ technology to speed up their drug discovery workflow.

View Video

cell-health-screening-3d-cell-culture

Validating Cell-Based Assays for Use with 3D Culture Models

Produced in collaboration with InSphero, this webinar presents the results from improved cell health assay protocols for 3D cultures.

View Webinar

technologies-cell-health-tile

BioIVT Named Service Provider for Promega Immunotherapy Bioassays

BioIVT announces that it will now offer Promega Immune Checkpoint and ADCC Reporter Bioassays to support immunology and immuno-oncology research. 

Read Press Release