Promega's Cookie Policy

We use cookies and similar technologies to make our website work, run analytics, improve our website, and show you personalized content and advertising. Some of these cookies are essential for our website to work. For others, we won’t set them unless you accept them. To find out more about cookies and how to manage cookies, read our Cookie Policy.

MEK Inhibitor U0126


Inhibits Activation of MAPK (ERK 1/2)

  • Used in both in vivo and in vitro studies of MEK
  • Potent: inhibits Raf-activated MEK1/2 in vitro with an IC50 of ~10–20μM
  • Supplied as a dried material


Catalog number selected: V1121

$ 256.00
Your price:
Please Enquire
This product is discontinued
Add to Helix
This product is available under our Early Access program - Learn More
This product is available under our Catalog (FT) program - Learn More
MEK Inhibitor U0126
$ 256.00
Your price: Log in

MEK Inhibitor U0126 is a chemically synthesized organic compound that inhibits activation of MAPK (ERK 1/2) by inhibiting the kinase activity of MAP Kinase Kinase (MAPKK or MEK 1/2). U0126 inhibits MEK1 with an IC50 of 0.5μM (in vitro). It has been used in both in vivo and in vitro studies of MEK. The chemical identity of MEK Inhibitor U0126 has been confirmed by proton NMR spectroscopy.

Supplied as a dried material. Resuspend 1mg in 234μl of DMSO to produce a stock solution of 10mM.


  1. DeSilva, D.R. et al. (1998) J. Immunol. 160, 4175–81.
  2. Favata, M. et al. (1998) J. Biol. Chem. 273, 18623–32.
  3. Goueli, S. et al. (1998) Promega Notes 69, 6–8.
  4. Tolwinski, N.S. et al. (1999) J. Biol. Chem. 274, 6168–74.
  5. Li, C. et al. (1999) J. Biol. Chem. 274, 6747–53.
  6. Duncia, J.V. et al. (1998) Bioorg. Med. Chem. Lett. 8, 2839–44.


What's in the box?

Item Part # Size

MEK Inhibitor U0126

V112A 5 × 1mg

Certificate of Analysis

Search by lot number

Use Restrictions

For Research Use Only. Not for Use in Diagnostic Procedures.

Storage Conditions


Store dried material at –20°C.

Let's find the product that meets your needs.

Talk to a Scientist