Connecting with Genealogical Roots
For generations the Greek maxim ‘know thyself’ has inspired many to search inwardly and externally about who they are. With modern scientific advances it has become more accessible for humans to discover exactly where their genealogical roots lie as a step on the journey to understand ourselves. With AncestryDNA, this process can be done easily from the comfort of your home. With a saliva sample AncestryDNA can estimate your origins to more than 350 regions around the world enabling you to get inspired by your past, connect with living relatives or complete missing pieces of your family tree.
The magic in that saliva sample that enables AncestryDNA to analyze your
past is genetic material called DNA, which must be extracted and
analyzed. As a result of AncestryDNA’s strong sales growth, a robust
laboratory workflow and reliable partner was required. This critical
workflow incorporates the Promega Maxwell® HT gDNA isolation chemistry,
which is used to process every sample. To date, over 7 million people
have used Ancestry DNA to better understand the journeys of their
ancestors that continues today in each us.
Bringing Solutions for Scientists in Pharmaceutical and Biotechnology Industries
Scientists within the pharmaceutical industry are continuously developing new small molecule drugs that can enter cells easily and affect specific target proteins. Targeted cancer therapies that block the growth and spread of cancer by interfering specifically with the disease cells, but not normal healthy cells are one example where small molecule drugs are used therapeutically. At early phases of drug development, researchers may need to screen more than 100,000 compounds at once to identify leads that can be further optimized and turned into new drugs. The availability of high-throughput compatible, reliable and predictable tools and assays reagents is crucial to the success of these researchers to discover new drugs that would be safe and effective in treating cancer patients.
Over the years, we have developed a broad portfolio of assay reagents that meet the needs of these pharmaceutical researchers and have been used widely during various phases of drug discovery and development. For example, our NanoBRET™ Target Engagement Assays allow researchers to quantitatively measure the interaction between a molecule and a protein in live cells reliably in a high-throughput manner. This is a significant advancement as these cellular assays can better predict compound performance. In addition to common drug targets like kinases, this NanoBRET™ Target Engagement technology has also been applied to CRISPR-Cas9 gene edited cells to help identify drugs that can lead to oncoprotein degradation.