White, J.H., Salehi-Tabar, R., Memari, B., Wong, H., Rochel, N.
Notes: The influence of vitamin D receptor (VDR) ligands on cancer and protein degradation is investigated. Specifically, FBW7, an E3 ligase involved in c-MYC degradation, is shown to interact with VDR and c-MYC, and the interaction is stimulated by 1,25-dihydroxyvitamin D3 (1,25D). Additionally, the MagneGST™ Pull-Down System was used to validate the VDR and c-MYC interaction in the presence of 1,25-dihydroxyvitamin D3 (1,25D). Together, these results show the interplay of vitamin D and cancer through FBW7 action. (5103)