Effects of soluble CPE on glioma cell migration are associated with mTOR activation and enhanced glucose flux.
Ilina, E., Armento, A., Sanchez, L.G., Reichlmeir, M., Braun, Y., Penski, C., Capper, D., Sahm, F., Jennewein, L., Harter, P.N., Zukunft, S., Fleming, I., Schulte, D., Le Guerroué, F., Behrends, C., Ronellenfitsch, M.W., Naumann, U., and Mittelbronn, M.
Notes: Carboxypeptidase E (CPE) regulates proliferation, migration and survival in several tumors. These authors showed that secreted CPE enhances glucose flux into the TCA cycle at the expense of lactate production, decreasing aerobic glycolysis. The Lactate-Glo™ and Glucose Uptake-Glo™ Assays were used to measure extracellular lactate in medium and glucose uptake, respectively.
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