Our website does not fully support your browser.

We've detected that you are using an older version of Internet Explorer. Your commerce experience may be limited. Please update your browser to Internet Explorer 11 or above.

We believe this site might serve you best:

United States

United States

Language: English

Promega's Cookie Policy

Our website uses functional cookies that do not collect any personal information or track your browsing activity. When you select your country, you agree that we can place these functional cookies on your device.

MagneSil® Genomic, Fixed Tissue System Technical Bulletin

Instructions for Use of Product(s)

Literature # TB319

The MagneSil® Genomic, Fixed Tissue System is designed to purify DNA from many formalin-fixed samples following an overnight Proteinase K digestion. Fragments up to 1.8kb in size have been successfully amplified from DNA purified with this system. One advantage this system has over other purification methods, such as phenol-chloroform extractions, is its ability to remove most amplification inhibitors, including very small fragments of DNA.

The MagneSil® Genomic, Fixed Tissue System was developed for use with small amounts of tissue such as those found in thin sections. To help eliminate inhibitors, a small amount of DNA-binding paramagnetic resin is used, and as a result the DNA-binding capacity of the system is limited to a few hundred nanograms. Use of a large amount of tissue will result in low recovery as well as poor-quality DNA when compared to other purification methods. Tissue that has been stored in formalin for extended periods of time may be too cross-linked or too degraded to perform as template for amplification.

Summary of Changes
The following changes were made to the 5/17 revision of this document:
1. Discontinued products were removed from Related Products.
2. The document design was updated.

Printed in USA. Revised 5/17