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GloResponse™ CRE-luc2P HEK293 Cell Line Technical Bulletin

Instructions for Use of Product(s)

Literature # TB362

The GloResponse™ CRE-luc2P HEK293 Cell Line is a clonal derivative of Human Embryonic Kidney 293 cells. These cells contain a luciferase gene (luc2P) under the control of a minimal Herpes Simplex Virus (HSV) thymidine kinase promoter with multiple cAMP response elements (CREs). CRE is the DNA-binding sequence for the transcription factor CRE binding protein (CREB), which is responsible for regulation of a variety of biological functions including cell proliferation, circadian rhythms and memory. The GloResponse™ CRE-luc2P HEK293 Cell Line is designed for rapid and convenient analysis of any cellular response that results in modulation of CREB activities.

Summary of Change
The following change was made to the 6/18 revision of this document:
The Description of the CRE-luc2P HEK293 Cell Line was edited to clarify that the cell line was generated using a pGL4.15[luc2P/Hygro] Vector containing a CRE response element and promoter.

Printed in USA. Revised 1/20