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CC1 pan-Kinase Inhibitor

For use as a control in the NanoBRET™ Target Engagement Intracellular Kinase Assays

  • Potent inhibitor to numerous kinases
  • For use with NanoBRET™ Target Engagement Intracellular Kinase Assays

Size

Catalog number selected: N2661

$ 250.00
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This product is discontinued
CC1 pan-Kinase Inhibitor
100μl
$ 250.00
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The CC1 pan-Kinase Inhibitor is a chemically synthesized compound that broadly binds to kinases, as determined using the NanoBRET™ Target Engagement (TE) Intracellular Kinase Assays. Using these assays, intracellular binding of this product is potent to numerous kinases including but not limited to ITK, NUAK1 and LRRK2, which produced 100% binding inhibition at 300nM. Representative IC50 data of this product for HIPK3 and SBK3 in NanoBRET™ TE Intracellular Kinase Assays is reported in Application Notes for NanoLuc®-HIPK3 (NV3231) and NanoLuc®-SBK3 (NV4211) fusion vectors, respectively.

Protocols using the CC1 pan-Kinase Inhibitor can be found in #TM598 and #TM603.

CC1 pan-kinase Inhibitor apparent cellular affinity for HIPK3 & SBK3.
CC1 pan-kinase Inhibitor apparent cellular affinity for HIPK3 & SBK3 determined via NanoBRET™ TE Intracellular Kinase Assays. HEK293 cells were transfected with NanoLuc®-HIPK3 Fusion vector (A) or NanoLuc®-SBK3 Fusion vector (B). To determine the apparent cellular affinity of CC1 pan-Kinase Inhibitor the Adherent method detailed in the NanoBRET™ TE Intracellular Kinase Assay Technical Manual #TM598 was followed. The recommended NanoBRET™ Tracer K-10 concentrations of 1µM for HIPK3 and 0.5µM for SBK were used.

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Specifications

What's in the box?

Item Part # SizeConcentration

CC1 pan-Kinase Inhibitor

N266A 1 × 100μl20mM

SDS

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Download SDSPDF (198 KB) – English (United States)

Use Restrictions

For Research Use Only. Not for Use in Diagnostic Procedures.

Storage Conditions

AA

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