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Alterations in Gene Expression

The development of cancer is driven by changes in the patterns of gene expression. Disruption of normal expression levels can lead to under- or overexpression of tumor suppressors and oncogenes, leading to tumorigenesis. Studying regulatory mechanisms and expression changes can help us better understand cancer biology and identify potential therapeutic targets.


microRNAs (miRNAs) play an important role in regulating thousands of human genes, including oncogenes and tumor suppressor genes. Gene expression studies could help us understand how miRNA dysregulation could lead to the development of many types of cancer.

Working with RNA

The transcriptome reflects the gene activity within a specific cell or tissue type. We can use this data to draw conclusions about normal and disrupted behavior.

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