Understanding how a small molecule compound interacts with its target protein is essential for developing successful drugs. Many potential drug candidates have entered clinical trials only to fail due to a poor understanding of how the drug interacts with its target in vivo. In vitro measurements of ligand affinity and duration of drug-target interactions (i.e., residence time) often do not translate in vivo. To bridge this gap, a system that relies on Bioluminescence Resonance Energy Transfer (BRET) to directly measure target engagement inside cells has been developed.
Sr Research Scientist, Group Leader
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