GTPase proteins are key cell signaling nodes regulating diverse cellular functions. Clinical manifestations associated with deregulation of GTPases, such as seen in XXXX and YYYY, illustrate the importance of this class of hydrolase enzymes. In fact mutations in Ras GTPases are associated with one-third of all human cancers.. However, measuring the activity of these important proteins is difficult. GTPases have a very high affinity for guanine nucleotides and are slow acting enzymes, two factors that make these enzymes difficult to measure. Adding to the complexity is the need for associated proteins to help facilitate GTP hydrolysis and nucleotide exchange.
Subhanjan Mondal, PhD
Senior Research Scientist
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