The Y-HRD Database: How It Works and How to Use It in Casework
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Lutz Roewer studied biochemistry at the University of Leipzig (Germany) and received his Ph.D. for molecular biology at the Humboldt-University Berlin (Germany) in 1991. His is currently an Associate Professor for Forensic Genetics at the Institute of Legal Medicine, Humboldt-University Berlin (Germany) and Director of the Department of Forensic Genetics at this institute.
Dr. Roewer has worked as a forensic expert since 1987. He is a specialist in the field of Y-chromosome genetics and its forensic, genealogical and anthropological applications. He is currently curator of the Y Chromosome Haplotype Reference Database (YHRD). He is member of the editorial boards of the journals, International Journal of Legal Medicine and Forensic Science International: Genetics. He has been a member of the SWGDAM Y-STR committee for the past 5 years. Dr. Roewer has authored more than 100 peer-reviewed articles in scientific journals, and publishes regular reviews and chapters in various textbooks.
Lutz Roewer, PhD
Head and Associate Professor of Forensic Genetics
Institute of Legal Medicine and Forensic Sciences, Charité University Hospital, Berlin, Germany
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Wednesday, May 8, 2019
The Y-Chromosome Haplotype Reference Database (Y-HRD) includes Y-chromosome haplotype data from 135 national databases populated over the past 20 years. Y-based ancestry prediction and familial searching can provide important investigative leads.
Join Dr. Roewer for this webinar as he discusses how to use the Y-HRD to facilitate statistical analyses for a range of casework applications and interpretation purposes (e.g., frequency estimation, kinship and mixture analysis and ancestry prediction).
Additional Webinar Information:
Today, Y-chromosome DNA typing is used to assist forensic investigations in a broad range of casework, either for rapid sexing of traces, for the identification and profiling of masked male DNA component(s) in mixtures with an excess of female DNA, for tracing male lineages in relationship testing, or for analyzing the ancestry of unidentified corpses or unknown trace donors. Like any forensic DNA analysis, judging the significance of a match between the trace and a reference person depends upon the population frequency of the DNA profile. The Y-Chromosome Haplotype Reference Database (Y-HRD) now includes 135 national databases populated over the past 20 years. These data facilitate statistical analyses for a range of casework applications and interpretation purposes (e.g., frequency estimation, kinship and mixture analysis, ancestry prediction). To calculate the Y-STR profile frequency constant and variable estimators can be used. The “Discrete Laplace method” implemented in the Y-HRD is a model-based extrapolation method that uses an in-depth analysis of Y-STR profiles in more than a thousand worldwide population samples. Moreover, the Y-HRD is a useful resource to infer the ancestry of an unknown male person due to the availability of a consensus phylogenetic tree and geographic and ethno-linguistic information assigned to each profile.