Epigenetics is the study of changes in phenotype casued by modification of gene expression rather than altercation of the genetic code itself. Bromodomain proteins, methyltransferases and demethylases, histone acetylases and deacetylases, are just a few proteins mediating the modification of gene expression. Aberrant expression of these and other important cellular proteins can lead to diseases such as cancer and inflammatory disorders. A significant goal of current research is to find modulators of epigenetic proteins and develop new therapeutics.
Researchers have made key discoveries in therapeutic epigenetic inhibitors recently. To better understand the mechanisms of action, we need to better elucidate how the inhibitors interact with their target proteins and identify any interacting partners, both on- and off-target. Dr. Danette Daniels will present new approaches using BRET (bioluminescence resonance energy transfer) to directly measure drug-target interactions and proteins binding to chromatin within live cells.
Danette Daniels, PhD
Senior Research Scientist
We love to talk science.
Sign up to receive monthly invitations to our webinars.