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J. Biol. Chem. 278, 14162 - 14167. Cross-talk between calpain and caspase proteolytic systems during neuronal apoptosis. 2003

Neumar, R.W., Xu, Y.A., Gada, H., Guttmann, R.P. and Siman R.

Notes: In this paper, researchers demonstrated that staurosporine-induced calpastatin degradation is prevented by the pan-caspase inhibitor Z-VAD-FMK. Stably transfected SH-SY5Y cells expressing calpastatin were pretreated with 50uM Z-VAD-FMK for an undisclosed amount of time before treatment with 0-0.5 µM staurosporine for 6 hours. Cell lysates were then analyzed by Western blotting to demonstrate the presence of caspase activity. (2668)

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FASEB J. 17, 458-460. Physiological electric fields control the G1/S phase cell cycle checkpoint to inhibit endothelial cell proliferation. 2003

Wang, E., Yin, Y., Zhao, M., Forrester, J.V. and McCaig, C.D.

Notes: The caspase Inhibitor Z-VAD-FMK was added to human umbilical vascular endothelial cell (VEC) cultures to examine its effect on proliferation when cells were subjected to an electric field. When added to cultures Z-VAD-FMK had no effect on proliferation of VECs.  (2827)

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Biol. Reprod. 64, 1183-1190. E-cadherin-mediated cell contact prevents apoptosis of spontaneously immortalized granulosa cells by regulating Akt kinase activity. 2001

Peluso, J.J., Pappalardo, A. and Fernandez G.

Notes: Spontaneously immortalized granulosa cells were incubated with 50μM of the pan-caspase inhibitor Z-VAD-FMK to demonstrate that apoptosis occurs after serum withdrawal or EGTA treatment. The inhibitor was added after treatment of the cells for 5 hours. Researchers also used Promega's Colorimetric CaspACE™ Assay System to measure caspase-3 activity in cell lysates. Results were expressed as fold increase in activity.  (2669)

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