Lutke Holzik, M.F., Storm, K., Sijmons, R.H., D’Hollander, M., Arts, E.G.J.M., Verstraaten, M.L., Sleijfer, D.T., and Hoekstra, H.J.
Notes: In this research study, a link between infertility due to deletions in the azoospermia factors of the Y chromosome and testicular germ cell tumors (TGCTs) was investigated. Genomic DNA isolated from peripheral blood lymphocytes of 112 Dutch patients confirmed to have TGCT was analyzed for deletions. The deletion analysis was performed using the Y Chromosome Deletion Detection System, Version 2.0 and the previous 1.0 system plus Master Mix E. The study finds that none of the TGCT patients had microdeletions in the AZF regions, thus suggesting a link between this type of infertility and TGCT is unlikely. (3243)