We will be conducting our annual physical inventory from March 11th through March 13th.

Orders received after 4pm CST on Tuesday, March 10th will be scheduled to ship as follows:

US Orders: Ship Saturday, March 14th for arrival on Monday, March 16th.
Canada Orders: Ship Monday, March 16th for arrival on Tuesday, March 17th.

Select items may ship earlier. For questions regarding the status of your order, contact custserv@promega.com.

Citations Search

Need Assistance

Sort By:

Clin. Can. Res. 8, 2035-2043. Validation of the pharmacodynamics of BMS-247550, an analogue of epothilone B, during a phase I clinical study 2002

McDaid, H.M., Mani, S., Shen, H-J., Muggia, F., Sonnichsen, D., Horwitz, S.B.

Notes: The authors investigated the mechanism of action of BMS-247550, a stable, synthetic derivative of epothilone B, in peripheral blood mononuclear cells and in breast tumor cells. Breast tumor cells expressing multidrug resistance were stained for tubulin bundle formation. Cytotoxicity in these biopsied cells also was examined by staining with Promega's Anti-PARP p85 Fragment, pAb. (2497)

Expand Full Notes »

Products

TMB One Solution

Choose your country

Americas

Brazil
/
Canada
/
United States
/

Pacific Asia

Australia
China
India
Japan
/
Republic of Korea
/
Singapore

Europe

Austria
/
Belgium
Denmark
(Incl. Faroe Isl. & Greenland)
Estonia
Finland
(Incl. Åland)
France
/
Germany
/
Iceland
Ireland
Italy
/
Luxembourg
Netherlands
Norway
(Incl. Svalbard)
Poland
/
Portugal
/
Spain
/
Sweden
Switzerland
United Kingdom

Manage Cookies

Necessary Cookies

We use these cookies to ensure our site functions securely and properly; they are necessary for our services to function and cannot be switched off in our systems. They are usually only set in response to actions made by you which amount to a request for services, such as logging in, using a shopping cart or filling in forms. You can set your browser to block or alert you about these cookies, but some parts of our services will not work without them. Like the other cookies we use, strictly necessary cookies may be either first-party cookies or third - party cookies.

Preference Cookies

We use these cookies to remember your settings and preferences. For example, we may use these cookies to remember your language preferences.

Performance/Statistics Cookies

We use these cookies to collect information about how you interact with our services and to help us measure and improve them. For example, we may use these cookies to determine if you have interacted with a certain page.

Marketing Cookies

We and our advertising partners use these cookies to deliver advertisements, to make them more relevant and meaningful to you, and to track the efficiency of our advertising campaigns, both on our services and on other websites and social media.

Your Privacy Choices

Our website supports your privacy choices by allowing users in select regions to opt out of specific types of sharing/sales/use of cookies and technologies for Targeted Advertising. Visit our Privacy Policy and Cookie Policy pages to learn more about these topics.

Targeted Advertising

Deselect this checkbox to disable cookies related to targeted advertising in your Promega experience. These advertising cookies will no longer be set for this browser and device.

Note: These settings are based on necessary cookies that are placed on your device, and if those cookies are cleared or you access the website from another browser or device, advertising cookies might be reset by default in the future, from which you can opt-out.