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Assay Guidance Manual . Cytotoxicity Assays: In Vitro Methods to Measure Dead Cells. 2019

Riss, T., Niles, A., Moravec, R., Karassina, N. and Vidugiriene, J.

Notes: This Assay Guidance Manual provides a resource to scientists optimizing assays used in drug discovery and development. The cytotoxicity chapter outlines several assays to detect dead cells, including LDH-Glo™, CytoTox-Glo™ and CellTox™ Green Cytotoxicity Assays, CellTiter-Glo® Luminescent Cell Viability Assay, CytoTox 96® Non-Radioactive Cytotoxicity Assay and CytoTox-ONE™ Homogeneous Membrane Integrity Assay. (5198)

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LDH-Glo™ Cytotoxicity Assay

CytoTox 96® Non-Radioactive Cytotoxicity Assay

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Lipids 53(11–12), 1021–1030. Large-Scale Screening of Natural Products Transactivating Peroxisome Proliferator-Activated Receptor α Identifies 9S-Hydroxy-10E,12Z,15Z-Octadecatrienoic Acid and Cymarin as Potential Compounds Capable of Increasing Apolipoprotein A-I Transcription in Human Liver Cells. 2018

van der Krieken, S.E., Popeijus, H.E., Bendik, I., Böhlendorf, B., Konings, M.C.J.M., Tayyeb, J., Mensink, R.P. and Plat, J.

Notes: Lactate dehydrogenase (LDH) release was used to monitor toxicity of compounds mediating apoA-I transcription on HepG2 cells. A luciferase reporter gene assay with renilla luciferase control was also used to evaluate the transactivation of PPARalpha. (5186)

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LDH-Glo™ Cytotoxicity Assay

Dual-Luciferase® Reporter Assay System

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