TGF-β concentrations and activity are down-regulated in the aqueous humor of patients with neovascular age-related macular degeneration.
Tosi, G.M., Neri, G., Caldi, E., Fusco, F., Bacci, T., Tarantello, A., Nuti, E., Marigliani, D., Baiocchi, S., Traversi, C., Barbarino, M., Eandi, C.M., Parolini, B., Mundo,d L., Santucci, A., Orlandini, M., Galvagni, F.
Notes: The role TGF-β in neovascular age-related macular degeneration (nAMD) is presently debated. Here, the levels of active TGF-β1, β2 and β3 proteins were measured in aqueous humor of patients with nAMD. The Nano-Glo® Dual-Luciferase® Reporter was then used to assess TGF-β pathway activation in Lenti-X 293T cells treated with aqueous humor from patients. Patients never treated with ranibizumab showed lower pathway activation compared to control or treated patients. Data here suggests a protective effect of TGF-β2 on nAMD. (5094)
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