Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC.
Laken, S.J., Petersen, G.M., Gruber, S.B., Oddoux, C., Ostrer, H., Giardiello, F.M., Hamilton, S.R., Hampel, H., Markowitz, A., Klimstra, D., Jhanwar, S., Winawer, S., Offit, K., Luce, M.C., Kinzler, K.W., Vogelstein, B.
Notes: This research was based upon the technique of Powell et al. (1993) to screen for APC mutations in Ashkenazi Jews. A mutation of APC, which carries a T-A transversion but does not have any truncating mutations, causes truncations of translation in the TNT® T7 Coupled Reticulocyte Lysate System. (0830)
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