MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state.
Poli, V., Fagnocchi, L., Fasciani, A., Cherubini, A., Mazzoleni, S., Ferrillo, S., Miluzio, A., Gaudioso, G., Vaira, V., Turdo, A., Gaggianesi, M., Chinnici, A., Lipari, E., Bicciato, S., Bosari, S., Todaro, M. and Zippo, A.
Notes: The pro-oncogene MYC has been shown to play a role in cell differentiation, growth and apoptosis. Here, MYC overexpression is shown to cause transcriptional reprogramming, leading to activation of oncogenic pathways and dedifferentiation. Interestingly, MYC reprogramming leads to a susceptible state where additional mutations are readily acquired. Mice were injected with luciferase-labeled tumor cells, and tumor metastasis was monitored using the VivoGlo™ Luciferin In Vivo Grade Substrate. (5145)
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