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Toxicology in Vitro 51, 83-94. High-throughput toxicity testing of chemicals and mixtures in organotypic multi-cellular cultures of primary human hepatic cells. 2018

Orbach, S.M., Ehrich, M.F., and Rajagopalan, P.

Notes: These authors describe the design, assembly and toxicant response of multi-cellular 3D hepatic organotypic culture models. In high-throughput screening, changes in cell viability were determined over 24 hours using the RealTime-Glo™ MT Cell Viability Assay. Mechanism of cell death was determined with the ApoTox-Glo™ Triplex Assay, and GSH concentration was measured using the GSH-Glo™ Glutathione Assay.  (5011)

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J. R. Soc. Interface 15, 20180236. A combined low-frequency electromagnetic and fluidic stimulation for a controlled drug release from superparamagnetic calcium phosphate nanoparticles: potential application for cardiovascular diseases. 2018

Marrella, A., Iafisco, M., Adamiano, A., Rossi, S., Aiello, M., Barandalla-Sobrados, M., Carullo, P., Miragoli, M., Tampieri, A., Scaglione, S. and Catalucci, D.

Notes: Researchers evaluated the use of magnetic nanoparticles and electromagnetic devices as a drug delivery approach with a possibility to treat cardiovascular disease. The biological effect on the cardiac system was evaluated using cardiomyocytes and measuring changes in cell viability, cytotoxicity, apoptosis and Reactive Oxygen Species (ROS) generation. (5029)

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J. Anesth. 32, 120–31. Cytotoxicity of propofol in human induced pluripotent stem cell-derived cardiomyocytes. 2018

Kido, K., Ito, H., Yamamoto, Y., Makita, K. and Uchida, T.

Notes: The ATP levels of human iPSC-derived cardiomyocytes were measured using the Mitochondrial ToxGlo™ Assay. To assess cell viability and caspase-3/7 activity, the ApoTox-Glo™ Triplex Assay was used and luminescence measured on a GloMax® plate reader for the caspase-3/7 assay. Cardiomyocytes were lysed and NAD+ and NADH measured from the same well using the NAD/NADH-Glo™ Assay to assess any changes in the NAD+/NADH ratio. (4952)

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EBioMedicine 33, 105–121. The circadian clock regulates metabolic phenotype rewiring via HKDC1 and modulates tumor progression and drug response in colorectal cancer. 2018

Fuhr, L., El-Athman, R., Scrima, R., Cela, O., Carbone, A., Knoop, H., Li, Y., Hoffmann, K., Laukkanen, M.O., Corcione, F., Steuer, R., Meyer, T.F., Mazzoccoli, G., Capitanio, N. and Relógio, A.

Notes: The ApoTox-Glo™ Triplex and CytoTox-Glo™ Cytotoxicity Assays were used to evaluate cell viability, cytotoxicity and apoptosis following cell treatments. (5040)

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Nat. Commun. 9, 2092. The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity. 2018

Bricambert, J., Alves-Guerra, M.C., Esteves, P., Prip-Buus, C., Bertrand-Michel, J., Guillou, H., Chang, C.J., Vander Wal, M.N., Canonne-Hergaux, F., Mathurin, P., Raverdy, V., Pattou, F., Girard, J., Postic, C. and Dentin, R.

Notes: The Nrf2-response element luciferase was used to measure transcriptional activity of a novel transcriptional activator Plant Homeodomain Finger 2 (Phf2). Interestingly, Phf2 was identified to protect the liver from Non Alcoholic Fatty Liver Disease (NAFLD) through histone demethylation. CGSH/GSSG-Glo™ was used to monitor glutathione content in the liver, while the ApoTox-Glo™ assay was used to monitor for cell viability and toxicity. (5179)

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Mol. Cell. Endocrinol. 447, 52–60. Endogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genes 2017

Shcherbina, L, Edlund, A., Esquerra, J.L., Abels, M., Zhous, Y, Ottosson-Laakso, E., Hansson, O., Eliasson, L. and Wierup, N.

Notes: The ApoTox-Glo™ Triplex Assay was used to determine cell viability, cytotoxicity and apoptosis at 72 hours after CART knockdown in islet cells. Cellular ATP levels during glucose-stimulated insulin secretion after CART knockdown in islet cells using the Mitochondrial ToxGlo™ Assay. (4954)

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PLos ONE 10, e0128445. Ketamine causes mitochondrial dysfunction in human induced pluripotent stem cell-derived neurons. 2015

Ito, H., Uchida, T. and Makita, K.

Notes: Induced pluripotent stem cells (iPSC) were differentiated into neurons and treated with 20, 100 and 500μM of ketamine for 6 and 24 hours to examine the neurotoxic effects of ketamine. The ApoTox-Glo™ Triplex Assay was used to examine cell viability and caspase-3/7 activation in the ketamine-treated iPSC-derived neurons. Fluorescence (cell viability) and luminescence (caspase-3/7 assay) was detected using a GloMax® multimode instrument. To examine if reactive oxygen species levels changed when iPSC-derived neurons were exposed to ketamine, the authors used the ROS-Glo™ H2O2 Assay with cells that were ketamine treated with or without a ROS scavenger for 6 and 24 hours. Luminescence was detected using a GloMax® instrument. Caspase activity was confirmed with or without the ROS scavenger using the Caspase-Glo® 3/7 Reagent from the ApoTox-Glo™ Triplex Assay. The levels of ketamine-induced oxidative stress were assessed in iPSC-derived neurons using the NAD/NADH-Glo™ Assay, and cellular ATP levels determined using the Mitochondrial ToxGlo™ Assay. The luminescence from both assays were measured on a GloMax® detection instrument. (4570)

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