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Case Study: Automated Protocol for DNA Extraction from Formalin-Fixed, Paraffin-Embedded (FFPE) Tissues

July, 2022

Overview

The Molecular Genetics of Cancer core lab of the University Hospital of Rennes initiated an automation project for DNA extraction from FFPE tissues. In addition to increasing throughput, the lab wanted to improve sample tracking and reproducibility of the results. The Promega Field Support Scientists (FSS) team assisted the researchers to develop an automated solution using their existing liquid handling system.

rennes-cs-workflow-schematic

Challenge

A clinical laboratory experiencing an increasing volume of FFPE biopsy samples needed a solution for extracting high-quality DNA and RNA to use in downstream diagnostic assays.

Solution

Automated processing using the Maxwell® HT extraction solutions and existing laboratory instruments increased the number of samples the laboratory could process and resulted in higher quality DNA than their current protocol.

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Maxwell® HT DNA FFPE Isolation System

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