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NanoBRET™ Protein Interaction Assays

We have developed NanoBRET™ Protein:Protein Interaction (PPI) Assays to measure the interaction of specific protein pairs for a variety of biological targets. Assays are available by direct order from our catalog or by custom order. Click on the catalog number to visit the product catalog page or check the box next to assays of interest to submit an inquiry to our Custom Assay Services team for more information.

Custom materials are developed by the Custom Assay Services team within R&D. Although functionally tested, they are not manufactured under the Promega ISO13485 quality system and are sold "as is" with no warranty either stated or implied.

  • Bromodomain Assays

    NameCatalog #
    NanoBRET™ BRD 4/Histone H3.3 Interaction AssayN1830
    NanoBRET™ BRD 4/Histone H4 Interaction AssayN1890
    NanoBRET™ BRD 9/Histone H3.3 Interaction AssayN1840
    NanoBRET™ BRD 9/Histone H4 Interaction AssayN1900
    NanoBRET™ BRPF1/Histone H3.3 Interaction AssayN1860
    NanoBRET™ BRPF1/Histone H4 Interaction AssayN1910
    NanoBRET™ CBP/Histone H3.3 Interaction AssayN1850


    Name
    ATAD2/Histone H3.3
    ATAD2/Histone H4
    BAZ2A/Histone H4
    BRD2 BD2/Histone H3.3
    BRD2/Histone H3.3
    BRD3 BD1/Histone H3.3
    BRD3 BD2 Histone H3 3
    BRD3/Histone H3.3
    BRD4 BD1BD2/Histone H3.3
    BRD4 BD2/Histone H3.3
    BRD7 BD/Histone H3.3
    BRD7/Histone H3.3
    BRDT/Histone H3.3
    BRPF1α BD1/Histone H3.3
    BRPF2/Histone H3.3
    BRPF3/Histone H3.3
    CBP BD/Histone H4
    CECR2 BD/Histone H3.3
    CECR2/Histone H3.3
    GCN5/Histone H3.3
    MLL1/Histone H3.3
    P300 BD/Histone H4
    PCAF/Histone H4
    SMARCA2/Histone H4
    TAF1(BD1BD2)/Histone H3.3
    Name
    ATAD2 BD/Histone H4
    BAZ2A/Histone H3.3
    BRD2 BD1/Histone H4
    BRD2 BD2/Histone H4
    BRD2/Histone H4
    BRD3 BD1/Histone H4
    BRD3 BD2 Histone H4
    BRD3/Histone H4
    BRD4 BD1BD2/Histone H4
    BRD4 BD2/Histone H4
    BRD7 BD/Histone H4
    BRD7/Histone H4
    BRDT/Histone H4
    BRPF1α BD1/Histone H4
    BRPF2/Histone H4
    BRPF3/Histone H4
    CBP/Histone H4
    CECR2 BD/Histone H4
    CECR2/Histone H4
    GCN5/Histone H4
    MLL1/Histone H4
    PCAF/Histone H3.3
    SMARCA2/Histone H3.3
    TAF1(BD1)/Histone H3.3
  • Other Epigenetic Assays

    Name
    CBX1/Histone H3.1
    CBX3/Histone H3.1
    CBX5/Histone H3.1
    CBX7/Histone H3.2
    EED1/Histone H3.1
    EZH2/Histone H3.3
    EZH2/Histone H3.1
    FANCD2/Ubiquitin
    KDM4A/Histone H3.3
    KDM4C/Histone H3.3
    KDM5A/Histone H3.3
    L3MBTL3 3MBT Domain/Histone H4
    LSD1/Histone H3.3
    MLL1/WDR5
    OGT/H2B
    PRMT1/H4
    PRMT5/WDR77(MEP50)
    TET3/Histone H3.3
    Name
    CBX2/H3.1
    CBX4/Histone H3.1
    CBX7/Histone H3.1
    CBX7/Histone H3.3
    EED1/Histone H3.3
    EZH2/EED1
    EZH2/SUZ12
    HDAC1/HDAC2
    KDM4B/Histone H3.3
    KDM4D/Histone H3.3
    L3MBTL1 Histone 4
    L3MBTL3/Histone H4
    MLL1/Menin
    OGT/H2A
    pHF19 Tudor/H3
    PRMT5/RIOK1
    SETD1A/Histone H3.3
    TUDOR/Histone H3.3
  • Membrane Protein Assays

    Name
    DAP12/Syk
    DAP12/TREM2 R47H
    HCN1/TRIP8b
    MET/Grb2
    MERTK dimer
    PD1/SHP-2
    STIM/Orai
    Name
    DAP12/TREM2
    GRB2/EGFR
    IL17RA/ACT1
    MET (D1228V)/Grb2
    MerTK dimer (mouse)
    SHC/EGFR
  • Cellular Regulation

    Name
    ABHD5/PLIN5
    CALR/MPL
    Name
    ABHD5/PNPLA3
    MCL-1/BIML
  • Signaling Proteins and Kinase Assays

    NameCatalog #
    NanoBRET™ KRas/BRaf Interaction AssayN1880


    Name
    β-catenin/APC
    β-catenin/BCL9L
    β-catenin/TCF3
    bRaf/bRaf (Dimerization)
    CD27/Traf2
    cRaf/cRaf (Dimerization)
    FKBP/FRB
    KRas(G12C)/cRaf
    KRas(WT)/bRaf
    MAVS/IFIH1
    MID1/Alpha4
    SKP1/SKP2
    SKP2/p27
    Name
    β-catenin/BCL9
    β-catenin/E-cadherin
    β-catenin/TCF4
    bRaf/cRaf
    cMyc/AURKA
    ERK/ELK
    KRas(G12C)/bRaf
    KRas(G12D)cRaf
    KRas (WT)/cRaf
    MEK/ERK
    MycN/AURKA
    SKP2/CKS1B
    TCF7L1/ß-catenin
  • Transcriptional Protein Assays

    NameCatalog #
    NanoBRET™ cMyc/MAX Interaction AssayN1870
    NanoBRET™ PPI Control Pair (p53/MDM2)N1641


    Name
    cMyc/AURKA
    EP300/HIF1a
    FOXP3/FOXP3
    GR/GR (Dimerization)
    HIF1α/Reptin
    HIF1α/VHL
    MED12/MED26
    SP140/Histone H3.3
    TEAD1/TAZ
    TEAD2/TAZ
    TEAD3/TAZ
    TEAD4/TAZ
    Name
    cMYc/WRD5
    ER/ER(Dimerization)
    FOXP3/NFATC2
    HIF1α/Pontin
    HIF1a/TIP60
    IRF/IRF (Dimerization)
    MycN/AURKA
    TCF7L1/β-catenin
    TEAD2/YAP
    TEAD3/YAP
    TEAD4/YAP
  • Protein Degradation

    Name
    β catenin/PSMD3, PSMD4, PSMD6
    BRD4/PSMD3
    BRD4/PSMD6
    CK1/CRBN
    E6/E6AP
    HIF1α/PSMD3, PSMD4, PSMD6
    P53/PSMD3, PSMD4, PSMD6
    Name
    BRD4/CRBN
    BRD4/PSMD4
    BRD4/VHL
    cMyc/PSMD3
    FANCD2(K561R)/Ubiquitin
    MycN/PSDM3
Name
Address