Our website does not fully support your browser.

We've detected that you are using an older version of Internet Explorer. Your commerce experience may be limited. Please update your browser to Internet Explorer 11 or above.

Promega's Cookie Policy

We use cookies and similar technologies to make our website work, run analytics, improve our website, and show you personalized content and advertising. Some of these cookies are essential for our website to work. For others, we won’t set them unless you accept them. To find out more about cookies and how to manage cookies, read our Cookie Policy.

Clinical MSI Testing IVD

Promega offers physicians a precision in vitro diagnostic assay for evaluating MSI status. The OncoMate™ MSI Dx Analysis System is an IVD medical device, leveraging the same validated gold standard Promega MSI loci relied on by global clinical researchers for almost two decades. The improved system offers reliable MSI determination with strong agreement to IHC.

Filter By


Assay Type

Accessories

Showing 3 of 3 Products

What is the Clinical Importance of MSI Status in Cancer?

MSI status is a biomarker that is used to identify candidates for further diagnostic testing for Lynch Syndrome. Lynch syndrome is a genetic predisposition to cancer caused by autosomal dominant mutations to the major mismatch repair genes MLH1, MSH2, MSH6 or PMS2 as well as the EPCAM gene that inactivates MSH2. Most often associated with colorectal cancer, Lynch syndrome also increases the lifetime risk of several other cancers including endometrial, ovarian and stomach cancer.

Universal screening of all colorectal cancer tumors for MSI status is recommended in guidelines by numerous physician-led organizations including the National Comprehensive Cancer Network (NCCN®)1 as well as the American Society for Clinical Pathology (ASCP), College of American Pathologists (CAP), Association for Molecular Pathology (AMP), American Society of Clinical Oncology (ASCO)2.

Learn more about MSI testing in the Microsatellite Instability Resource Center.

  1. To view the most recent and complete version of NCCN Guidelines®, go online to nccn.org.
  2. Sepulveda, A.R., et al. (2017) J. Mol. Diag. 19, 187–225.

From questions to in-person trainings, our team of experts is here to help your clinical lab run smoothly.

Contact Us
scientist-us-joliene