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Studying PROTAC-Mediated Protein Degradation

In this presentation, Promega Senior Research Scientist Jim Vasta explains how NanoBRET™ technology can be used to determine cellular permeability and target engagement of PROTAC drug candidates.

NanoBRET™ Technology is revolutionizing the study of protein:protein and protein:ligand interactions, allowing in-vivo analysis and quantification of protein dynamics at physiological levels.

The sensitivity of this detection method expands the applications of BRET and allows the development of plate-based assays to screen and quantify drug:target interactions in living cells at scale.

Learn More About NanoBRET Protein Degradation Tools