MAPK6, mitogen-activated protein kinase 6

MAPK6, mitogen-activated protein kinase 6

• The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]

• Gene Synonyms (mitogen-activated protein kinase 6, ERK-3, MAP kinase 6, MAP kinase isoform p97, MAPK 6, extracellular signal-regulated kinase 3, extracellular signal-regulated kinase, p97, p97-MAPK, protein kinase, mitogen-activated 5, protein kinase, mitogen-activated 6, ERK3, HsT17250, PRKM6, p97MAPK,)
• NCBI Gene ID: 5597
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q16659
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mitogen-activated protein kinase 6 interacts with:

• 2-hydroxyacyl-CoA lyase 1
  actin related protein 1B
  actin related protein 2/3 complex subunit 3
  adaptor related protein complex 3 subunit delta 1
  adhesion regulating molecule 1
  ADP ribosylation factor GTPase activating protein 2
  ADP ribosylation factor GTPase activating protein 3
  ADP ribosylation factor like GTPase 6 interacting protein 1
  A-kinase anchoring protein 8 like
  aladin WD repeat nucleoporin
  aminoacyl tRNA synthetase complex interacting multifunctional protein 2
  anaphase promoting complex subunit 5
  ankyrin repeat and KH domain containing 1
  ankyrin repeat domain 2
  aquarius intron-binding spliceosomal factor
  armadillo repeat containing X-linked 5
  assembly factor for spindle microtubules
  ataxin 10
  ATP binding cassette subfamily D member 3
  ATP synthase peripheral stalk subunit d
  ATPase family AAA domain containing 3A
  ATPase H+ transporting accessory protein 2
  ATPase H+ transporting V1 subunit H
  aurora kinase A
  aurora kinase B
  autophagy and beclin 1 regulator 1
  autophagy related 9A
  B cell receptor associated protein 31
  BAG cochaperone 2
  BAG cochaperone 6
  Bardet-Biedl syndrome 10
  BARX homeobox 1
  branched chain keto acid dehydrogenase kinase
  calmodulin like 5
  caseinolytic mitochondrial matrix peptidase chaperone subunit X
  CDP-diacylglycerol--inositol 3-phosphatidyltransferase
  cell division cycle 7
  centriolin
  centrosomal protein 170
  centrosomal protein 55
  ceramide synthase 1
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 3
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  choline/ethanolamine phosphotransferase 1
  cilia and flagella associated protein 298
  COP9 signalosome subunit 6
  cullin 7
  CYFIP related Rac1 interactor B
  cytohesin 2
  DEAH-box helicase 40
  dermcidin
  developmental pluripotency associated 4
  DExH-box helicase 34
  diacylglycerol kinase zeta
  DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
  DnaJ heat shock protein family (Hsp40) member A2
  DnaJ heat shock protein family (Hsp40) member A3
  DnaJ heat shock protein family (Hsp40) member B12
  DnaJ heat shock protein family (Hsp40) member B6
  DnaJ heat shock protein family (Hsp40) member C28
  DnaJ heat shock protein family (Hsp40) member C7
  dynactin subunit 2
  dynein 2 intermediate chain 2
  dynein light chain LC8-type 1
  ecdysoneless cell cycle regulator
  Ecm29 proteasome adaptor and scaffold
  eEF1A lysine and N-terminal methyltransferase
  egl-9 family hypoxia inducible factor 3
  elongation factor 1 homolog
  elongator complex protein 1
  endothelial differentiation related factor 1
  enoyl-CoA delta isomerase 2
  eukaryotic translation initiation factor 1
  eukaryotic translation initiation factor 3 subunit C
  exportin 1
  FA complementation group I
  FAD dependent oxidoreductase domain containing 2
  family with sequence similarity 162 member A
  Fas associated factor family member 2
  fatty acyl-CoA reductase 1
  F-box and leucine rich repeat protein 16
  FUN14 domain containing 2
  glutaredoxin 3
  golgi reassembly stacking protein 1
  GPN-loop GTPase 1
  guided entry of tail-anchored proteins factor 4
  HAUS augmin like complex subunit 2
  HCLS1 associated protein X-1
  heat shock protein 90 beta family member 1
  heat shock protein family A (Hsp70) member 4 like
  heat shock protein family H (Hsp110) member 1
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  heterogeneous nuclear ribonucleoprotein A0
  HIG1 hypoxia inducible domain family member 1A
  histone deacetylase 11
  hook microtubule tethering protein 1
  hydroxysteroid dehydrogenase like 2
  ilvB acetolactate synthase like
  importin 7
  importin 9
  insulin receptor substrate 4
  integrin subunit beta 3 binding protein
  intersectin 1
  kinetochore localized astrin (SPAG5) binding protein
  leupaxin
  lon peptidase 1, mitochondrial
  lon peptidase 2, peroxisomal
  LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
  MAGE family member D1
  MAGE family member D2
  mannan binding lectin serine peptidase 1
  MAP3K12 binding inhibitory protein 1
  MAPK activated protein kinase 5
  MAPK associated protein 1
  marginal zone B and B1 cell specific protein
  membrane associated ring-CH-type finger 7
  membrane bound O-acyltransferase domain containing 7
  methyltransferase like 17
  methyltransferase like 2A
  MIS18 kinetochore protein A
  mitochondrial carrier 2
  mitochondrial fission factor
  mitochondrial ribosome associated GTPase 2
  mitogen-activated protein kinase 6
  mitogen-activated protein kinase kinase kinase 12
  mitogen-activated protein kinase kinase kinase 7
  MOK protein kinase
  MON1 homolog A, secretory trafficking associated
  MYC binding protein 2
  myeloid leukemia factor 2
  myozenin 3
  N-acetyltransferase 9 (putative)
  NAD(P)HX epimerase
  NADH:ubiquinone oxidoreductase complex assembly factor 4
  nectin cell adhesion molecule 2
  negative elongation factor complex member B
  neuralized E3 ubiquitin protein ligase 4
  neurexin 2
  nuclear receptor coactivator 4
  nucleolar protein 4
  nucleoside-triphosphatase, cancer-related
  nudix hydrolase 5
  osteoclast stimulating factor 1
  PC4 and SFRS1 interacting protein 1
  PDZ and LIM domain 1
  phosphatase and actin regulator 3
  phosphoglycerate dehydrogenase
  phosphoserine aminotransferase 1
  PIH1 domain containing 1
  pleckstrin homology and RUN domain containing M1
  PNKD metallo-beta-lactamase domain containing
  polypeptide N-acetylgalactosaminyltransferase 7
  PRA1 domain family member 2
  prefoldin subunit 6
  pre-mRNA processing factor 38A
  presequence translocase associated motor 16
  programmed cell death 6 interacting protein
  proteasome 20S subunit alpha 2
  proteasome 20S subunit alpha 7
  proteasome 20S subunit beta 2
  proteasome 20S subunit beta 3
  proteasome 20S subunit beta 4
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 3
  proteasome 26S subunit, ATPase 4
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 1
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 12
  proteasome 26S subunit, non-ATPase 13
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 2
  proteasome 26S subunit, non-ATPase 3
  proteasome 26S subunit, non-ATPase 4
  proteasome 26S subunit, non-ATPase 6
  proteasome 26S subunit, non-ATPase 7
  proteasome 26S subunit, non-ATPase 8
  proteasome activator subunit 1
  proteasome activator subunit 2
  proteasome activator subunit 3
  protein tyrosine phosphatase mitochondrial 1
  PTOV1 extended AT-hook containing adaptor protein
  PTPRF interacting protein alpha 1
  RAB2A, member RAS oncogene family
  RAB31, member RAS oncogene family
  RAD23 homolog B, nucleotide excision repair protein
  RAD50 double strand break repair protein
  Raf-1 proto-oncogene, serine/threonine kinase
  RAN binding protein 9
  RAP1 GTPase activating protein
  RB transcriptional corepressor like 1
  receptor for activated C kinase 1
  regulator of G protein signaling 19
  replication timing regulatory factor 1
  reticulon 4
  retinoic acid receptor alpha
  ribosomal L1 domain containing 1
  ribosomal protein L10
  ribosomal protein S27
  ribosomal protein S27 like
  ribosomal protein S27a
  ribosomal RNA processing 7 homolog A
  ring finger protein 126
  RNA polymerase I and III subunit C
  RNA polymerase I subunit A
  RPA1 related single stranded DNA binding protein, X-linked
  RPTOR independent companion of MTOR complex 2
  selenoprotein K
  septin 3
  sequestosome 1
  serine and arginine rich splicing factor 5
  serine palmitoyltransferase long chain base subunit 1
  serine/threonine kinase 40
  serpin family B member 4
  SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
  SHC adaptor protein 1
  sideroflexin 1
  single stranded DNA binding protein 1
  small glutamine rich tetratricopeptide repeat containing alpha
  small nuclear RNA activating complex polypeptide 4
  small proline rich protein 2D
  small ubiquitin like modifier 2
  SNW domain containing 1
  solute carrier family 1 member 5
  solute carrier family 16 member 1
  solute carrier family 20 member 1
  solute carrier family 25 member 11
  solute carrier family 25 member 13
  solute carrier family 27 member 4
  solute carrier family 41 member 3
  solute carrier family 7 member 1
  solute carrier family 7 member 5
  spartin
  spectrin alpha, non-erythrocytic 1
  spermine synthase
  SPG7 matrix AAA peptidase subunit, paraplegin
  stearoyl-CoA desaturase
  STIP1 homology and U-box containing protein 1
  stress induced phosphoprotein 1
  suppressor of cytokine signaling 3
  synapse associated protein 1
  syntaxin 7
  t-complex 1
  telomere maintenance 2
  testis expressed 264, ER-phagy receptor
  THAP domain containing 4
  thymopoietin
  torsin 1A interacting protein 1
  TRAF-type zinc finger domain containing 1
  transcription elongation factor A like 1
  transferrin
  translocase of inner mitochondrial membrane 50
  translocase of outer mitochondrial membrane 20
  translocase of outer mitochondrial membrane 34
  transmembrane 9 superfamily member 2
  transmembrane and coiled-coil domains 1
  transmembrane BAX inhibitor motif containing 6
  transmembrane p24 trafficking protein 7
  transmembrane protein 165
  transmembrane protein 41B
  triosephosphate isomerase 1
  tripartite motif containing 25
  tripartite motif containing 33
  TRPM8 channel associated factor 1
  TTK protein kinase
  tubulin alpha 1a
  tubulin beta 2A class IIa
  tumor protein D52
  tumor protein p53
  tyrosyl-DNA phosphodiesterase 2
  ubiquinol-cytochrome c reductase hinge protein
  ubiquitin A-52 residue ribosomal protein fusion product 1
  ubiquitin C
  ubiquitin conjugating enzyme E2 L3
  ubiquitin conjugating enzyme E2 O
  ubiquitin C-terminal hydrolase L5
  ubiquitin like 4A
  ubiquitin protein ligase E3 component n-recognin 5
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 11
  ubiquitin specific peptidase 20
  URB1 ribosome biogenesis homolog
  vesicle amine transport 1
  vesicle associated membrane protein 7
  vimentin
  voltage dependent anion channel 1
  voltage dependent anion channel 2
  VPS18 core subunit of CORVET and HOPS complexes
  VPS26 endosomal protein sorting factor C
  WAPL cohesin release factor
  WD repeat domain 26
  WD repeat domain 6
  wolframin ER transmembrane glycoprotein
  WW and C2 domain containing 1
  zinc finger protein 133
  zinc finger protein 205
  zinc finger protein 24
  zinc finger protein 28
  zinc finger protein 281
  zinc finger protein 331
  zinc finger protein 579
  zinc finger protein 600
  zinc finger protein 671
  zinc finger protein 7
  zinc finger protein 775
  zinc finger protein 813
  zinc finger protein 92
  zinc ribbon domain containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.