NCOA4, nuclear receptor coactivator 4

NCOA4, nuclear receptor coactivator 4

• This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]

• Gene Synonyms (nuclear receptor coactivator 4, 70 kDa AR-activator, 70 kDa androgen receptor coactivator, NCoA-4, RET-activating gene ELE1, androgen receptor-associated protein of 70 kDa, ret fused, ARA70, ELE1, PTC3, RFG,)
• NCBI Gene ID: 8031
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13772
  UNIPROT ID#>>B2R5V0
  UNIPROT ID#>>A0A024QZI5
  UNIPROT ID#>>Q96E88
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nuclear receptor coactivator 4 interacts with:

• bone morphogenetic protein receptor, type 1A
  CDC23 cell division cycle 23
  egl-9 family hypoxia inducible factor 3
  germ cell-less 1, spermatogenesis associated
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  kinesin family member 1B
  kinesin family member 21A
  lysine acetyltransferase 2B
  midline 2
  neuralized E3 ubiquitin protein ligase 4
  proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
  proteasome 26S subunit, non-ATPase 14
  ring finger protein 14
  Tax1 binding protein 1
  trafficking from ER to golgi regulator
  ubiquitin specific peptidase 43
  WD repeat domain 61

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.