MASP1, mannan binding lectin serine peptidase 1

MASP1, mannan binding lectin serine peptidase 1

• This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

• Gene Synonyms (mannan-binding lectin serine protease 1, C4/C2 activating component of Ra-reactive factor, Ra-reactive factor serine protease p100, complement factor MASP-3, complement-activating component of Ra-reactive factor, mannose-binding lectin-associated serine protease 1, mannose-binding protein-associated serine protease, serine protease 5, 3MC1, CRARF, CRARF1, MAP1, MASP, MASP3, MAp44, PRSS5, RaRF,)
• NCBI Gene ID: 5648
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P48740
  UNIPROT ID#>>F8W876
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mannan binding lectin serine peptidase 1 interacts with:

• cell division cycle 37, HSP90 cochaperone
  cullin 3
  cyclin dependent kinase 19
  ERBB receptor feedback inhibitor 1
  mannan binding lectin serine peptidase 2
  mitogen-activated protein kinase 8 interacting protein 2
  NCK adaptor protein 2
  nudix hydrolase 21
  programmed cell death 6 interacting protein
  ribosomal protein S6 kinase A3
  ribosomal protein S6 kinase A6
  ubiquitin recognition factor in ER associated degradation 1

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