MASP2, mannan binding lectin serine peptidase 2

MASP2, mannan binding lectin serine peptidase 2

• This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

• Gene Synonyms (MAP19, MASP-2, MASP1P1, sMAP, mannan-binding lectin serine protease 2, MBL-associated plasma protein of 19 kD, MBL-associated serine protease 2, mannan-binding lectin serine peptidase 1 pseudogene 1, mannan-binding lectin serine protease 1 pseudogene 1, mannose-binding protein-associated serine protease 2, small MBL-associated protein,)
• NCBI Gene ID: 10747
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O00187
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mannan binding lectin serine peptidase 2 interacts with:

• mannan binding lectin serine peptidase 2
  solute carrier family 16 member 8

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