NUDT5, nudix hydrolase 5

NUDT5, nudix hydrolase 5

• This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013]

• Gene Synonyms (ADP-sugar pyrophosphatase, 8-oxo-dGDP phosphatase, nuclear ATP-synthesis protein NUDIX5, nudix (nucleoside diphosphate linked moiety X)-type motif 5, YSA1, YSA1H, YSAH1, hNUDT5,)
• NCBI Gene ID: 11164
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UKK9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nudix hydrolase 5 interacts with:

• BICD cargo adaptor 2
  golgi reassembly stacking protein 2
  MAD2 mitotic arrest deficient-like 1
  nudix hydrolase 3
  nudix hydrolase 5
  pyrroline-5-carboxylate reductase 2
  SMAD specific E3 ubiquitin protein ligase 1
  spindle and kinetochore associated complex subunit 1
  spindle and kinetochore associated complex subunit 3
  tripartite motif containing 47

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.