PSMB4, proteasome 20S subunit beta 4

PSMB4, proteasome 20S subunit beta 4

• The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. [provided by RefSeq, Jul 2008]

• Gene Synonyms (proteasome subunit beta type-4, 26 kDa prosomal protein, hsBPROS26, macropain beta chain, multicatalytic endopeptidase complex beta chain, proteasome (prosome, macropain) subunit, beta type, 4, proteasome beta chain, proteasome chain 3, proteasome subunit HsN3, proteasome subunit beta 4, proteasome subunit beta7, proteasome subunit, beta type, 4, testis tissue sperm-binding protein Li 79P, HN3, HsN3, PRAAS3, PROS-26, PROS26,)
• NCBI Gene ID: 5692
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A140VK46
  UNIPROT ID#>>P28070
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proteasome 20S subunit beta 4 interacts with:

• adhesion regulating molecule 1
  anterior gradient 2, protein disulphide isomerase family member
  BAG cochaperone 3
  cereblon
  chloride intracellular channel 4
  chromosome 1 open reading frame 109
  cleavage and polyadenylation specific factor 2
  coiled-coil domain containing 57
  cullin 1
  cullin 7
  deltex E3 ubiquitin ligase 2
  F-box protein 38
  F-box protein 7
  fibronectin type III and SPRY domain containing 2
  forkhead box J3
  forkhead box P3
  GABA type A receptor associated protein like 1
  grancalcin
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  HemK methyltransferase family member 1
  hepatocyte growth factor-regulated tyrosine kinase substrate
  IQ motif containing B1
  keratin associated protein 19-5
  KN motif and ankyrin repeat domains 2
  L3MBTL histone methyl-lysine binding protein 1
  La ribonucleoprotein 7, transcriptional regulator
  limb development membrane protein 1 like
  myozenin 3
  negative elongation factor complex member E
  negative regulator of ubiquitin like proteins 1
  NHL repeat containing 2
  obscurin like cytoskeletal adaptor 1
  peroxisomal biogenesis factor 19
  pre-mRNA processing factor 19
  prolyl 4-hydroxylase subunit alpha 3
  proteasome (prosome, macropain) subunit, beta type 5
  proteasome 20S subunit alpha 8
  proteasome 20S subunit beta 10
  proteasome 20S subunit beta 5
  proteasome 20S subunit beta 6
  proteasome 20S subunit beta 7
  proteasome 20S subunit beta 8
  proteasome 20S subunit beta 9
  proteasome 26S subunit, ATPase 1
  proteasome 26S subunit, ATPase 2
  proteasome 26S subunit, ATPase 3
  proteasome 26S subunit, ATPase 4
  proteasome 26S subunit, ATPase 5
  proteasome 26S subunit, ATPase 6
  proteasome 26S subunit, non-ATPase 1
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 12
  proteasome 26S subunit, non-ATPase 13
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 2
  proteasome 26S subunit, non-ATPase 3
  proteasome 26S subunit, non-ATPase 4
  proteasome 26S subunit, non-ATPase 5
  proteasome 26S subunit, non-ATPase 6
  proteasome 26S subunit, non-ATPase 7
  proteasome 26S subunit, non-ATPase 8
  proteasome 26S subunit, non-ATPase 9
  proteasome activator subunit 1
  proteasome activator subunit 2
  proteasome activator subunit 3
  proteasome activator subunit 4
  proteasome assembly chaperone 1
  proteasome assembly chaperone 2
  proteasome assembly chaperone 3
  proteasome inhibitor subunit 1
  proteasome maturation protein
  protein tyrosine phosphatase non-receptor type 11
  protein tyrosine phosphatase non-receptor type 2
  RAB11A, member RAS oncogene family
  RAD23 homolog A, nucleotide excision repair protein
  RecQ like helicase 4
  ribonuclease P/MRP subunit p38
  SEM1 26S proteasome complex subunit
  SLX4 structure-specific endonuclease subunit
  spermatogenesis and oogenesis specific basic helix-loop-helix 1
  SPG21 abhydrolase domain containing, maspardin
  S-phase kinase associated protein 1
  sulfotransferase family 1A member 4
  synapse associated protein 1
  synaptopodin 2 like
  synoviolin 1
  tektin 5
  TNFAIP3 interacting protein 2
  transcription factor AP-2 delta
  transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L5
  ubiquitin D
  ubiquitin like modifier activating enzyme 2
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 15
  ubiquitin specific peptidase 7
  ubiquitin specific peptidase 9 X-linked
  vir like m6A methyltransferase associated
  Yes1 associated transcriptional regulator
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.