PSMD2, proteasome 26S subunit, non-ATPase 2

PSMD2, proteasome 26S subunit, non-ATPase 2

• The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

• Gene Synonyms (26S proteasome non-ATPase regulatory subunit 2, 55.11 protein, TNFR-associated protein 2, proteasome (prosome, macropain) 26S subunit, non-ATPase, 2, protein 55.11, tumor necrosis factor type 1 receptor-associated protein 2, P97, RPN1, S2, TRAP2,)
• NCBI Gene ID: 5708
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13200
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

proteasome 26S subunit, non-ATPase 2 interacts with:

• AAR2 splicing factor
  activator of HSP90 ATPase activity 1
  adhesion regulating molecule 1
  ankyrin repeat and SOCS box containing 11
  anterior gradient 2, protein disulphide isomerase family member
  asporin
  ataxin 7
  autophagy and beclin 1 regulator 1
  autophagy related 4C cysteine peptidase
  BAG cochaperone 3
  BRCA1 associated protein 1
  cell division cycle 73
  chaperonin containing TCP1 subunit 2
  coiled-coil domain containing 74B
  coiled-coil domain containing 8
  coiled-coil domain containing 92
  complexin 1
  COPI coat complex subunit epsilon
  cullin 3
  cullin 7
  derlin 1
  dual specificity phosphatase 15
  dynamin 1 like
  ecdysoneless cell cycle regulator
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  ER lipid raft associated 2
  Fas associated factor family member 2
  F-box protein 25
  FKBP prolyl isomerase 8
  G3BP stress granule assembly factor 1
  gap junction protein gamma 1
  glutamate rich WD repeat containing 1
  HECT and RLD domain containing E3 ubiquitin protein ligase 3
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 4
  histone deacetylase 5
  homocysteine inducible ER protein with ubiquitin like domain 1
  importin 9
  JNK1/MAPK8 associated membrane protein
  kelch like ECH associated protein 1
  kinase suppressor of ras 1
  L3MBTL histone methyl-lysine binding protein 1
  La ribonucleoprotein 7, transcriptional regulator
  ligand dependent nuclear receptor interacting factor 1
  limb development membrane protein 1 like
  methylphosphate capping enzyme
  midline 2
  mitochondrial carrier 1
  mitogen-activated protein kinase kinase kinase 13
  moesin
  Nanog homeobox
  negative regulator of ubiquitin like proteins 1
  neutrophil cytosolic factor 1
  NHL repeat containing 2
  NIMA related kinase 6
  N-myc downstream regulated 1
  NSFL1 cofactor
  nuclear receptor subfamily 2 group C member 2
  nuclear RNA export factor 1
  obscurin like cytoskeletal adaptor 1
  OFD1 centriole and centriolar satellite protein
  patched 1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  pleiotrophin
  pre-mRNA processing factor 8
  proteasomal ATPase associated factor 1
  proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
  proteasome (prosome, macropain) subunit, beta type 5
  proteasome 20S subunit alpha 8
  proteasome 26S subunit, non-ATPase 10
  proteasome 26S subunit, non-ATPase 11
  proteasome 26S subunit, non-ATPase 12
  proteasome 26S subunit, non-ATPase 13
  proteasome 26S subunit, non-ATPase 14
  proteasome 26S subunit, non-ATPase 2
  proteasome 26S subunit, non-ATPase 3
  proteasome 26S subunit, non-ATPase 4
  proteasome 26S subunit, non-ATPase 5
  proteasome 26S subunit, non-ATPase 6
  proteasome 26S subunit, non-ATPase 7
  proteasome 26S subunit, non-ATPase 8
  proteasome 26S subunit, non-ATPase 9
  proteasome activator subunit 2
  proteasome activator subunit 3
  proteasome maturation protein
  protein phosphatase, Mg2+/Mn2+ dependent 1D
  protein tyrosine phosphatase 4A1
  protein tyrosine phosphatase non-receptor type 2
  protein tyrosine phosphatase non-receptor type 6
  protein tyrosine phosphatase receptor type O
  PTEN induced kinase 1
  RAD21 cohesin complex component
  RAD23 homolog A, nucleotide excision repair protein
  RAD23 homolog B, nucleotide excision repair protein
  RecQ like helicase 4
  regulatory associated protein of MTOR complex 1
  ribonuclease/angiogenin inhibitor 1
  ribosomal protein S12
  ribosomal protein S21
  ring finger and CCCH-type domains 2
  ring finger protein 11
  ring finger protein 4
  SEC24 homolog A, COPII coat complex component
  SEM1 26S proteasome complex subunit
  sirtuin 7
  slingshot protein phosphatase 1
  SMAD specific E3 ubiquitin protein ligase 1
  small ubiquitin like modifier 1
  snail family transcriptional repressor 1
  SNW domain containing 1
  staufen double-stranded RNA binding protein 1
  STEAP family member 1
  succinate dehydrogenase complex flavoprotein subunit A
  sulfiredoxin 1
  SUMO specific peptidase 3
  superoxide dismutase 1
  synapsin I
  synaptotagmin binding cytoplasmic RNA interacting protein
  synoviolin 1
  tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
  TBC1 domain family member 3B
  TBC1 domain family member 3G
  terminal nucleotidyltransferase 4B
  thioredoxin like 1
  thymopoietin
  TNF receptor superfamily member 1A
  transformation related protein 53 binding protein 1
  transmembrane protein 41B
  transmembrane protein 67
  tripartite motif containing 11
  tripartite motif containing 25
  tropomyosin 4
  tumor protein p53 binding protein 1
  tumor protein p63
  U2 small nuclear RNA auxiliary factor 2
  ubiquilin 1
  ubiquilin 2
  ubiquilin 4
  ubiquitin C
  ubiquitin conjugating enzyme E2 L3
  ubiquitin conjugating enzyme E2 M
  ubiquitin C-terminal hydrolase L5
  ubiquitin like domain containing CTD phosphatase 1
  ubiquitin like modifier activating enzyme 5
  ubiquitin protein ligase E3A
  ubiquitin protein ligase E3C
  ubiquitin recognition factor in ER associated degradation 1
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 15
  UBX domain protein 6
  UBX domain protein 7
  unc-119 lipid binding chaperone
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  von Hippel-Lindau tumor suppressor
  VPS9 domain containing 1
  WD repeat containing, antisense to TP73
  Yes1 associated transcriptional regulator
  zinc finger and BTB domain containing 1
  zinc finger and BTB domain containing 16
  zinc finger and BTB domain containing 39
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.