CCT2, chaperonin containing TCP1 subunit 2

CCT2, chaperonin containing TCP1 subunit 2

• The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

• Gene Synonyms (99D8.1, CCT-beta, CCTB, HEL-S-100n, PRO1633, TCP-1-beta, T-complex protein 1 subunit beta, T-complex protein 1, beta subunit, chaperonin containing TCP1, subunit 2 (beta), chaperonin containing t-complex polypeptide 1, beta subunit, chaperonin containing t-complex polypeptide 1, subunit 2, epididymis secretory sperm binding protein Li 100n,)
• NCBI Gene ID: 10576
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P78371
  UNIPROT ID#>>V9HW96
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

chaperonin containing TCP1 subunit 2 interacts with:

• AAR2 splicing factor
  actin beta like 2
  actin related protein 3B
  activator of HSP90 ATPase activity 1
  alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
  armadillo repeat containing 6
  ARP1 actin-related protein 1B, centractin beta
  autophagy and beclin 1 regulator 1
  autophagy related 16 like 1
  B9 domain containing 1
  calmodulin-lysine N-methyltransferase
  caveolae associated protein 3
  cell division cycle 20
  cell division cycle 73
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 6B
  chaperonin containing TCP1 subunit 8
  chaperonin containing Tcp1, subunit 3 (gamma)
  chaperonin containing Tcp1, subunit 4 (delta)
  chaperonin containing Tcp1, subunit 7 (eta)
  chaperonin containing Tcp1, subunit 8 (theta)
  chromobox 5
  chromosome 11 open reading frame 54
  coiled-coil domain containing 8
  COP1 E3 ubiquitin ligase
  COP9 signalosome subunit 5
  cortactin binding protein 2
  cyclin dependent kinase 11A
  cyclin dependent kinase 15
  cytochrome b5 type B
  DDB1 and CUL4 associated factor 10
  DDB1 and CUL4 associated factor 11
  DDB1 and CUL4 associated factor 4
  DDB1 and CUL4 associated factor 8
  denticleless E3 ubiquitin protein ligase
  DnaJ heat shock protein family (Hsp40) member A4
  dynein 2 intermediate chain 2
  dynein axonemal intermediate chain 2
  EEF1A lysine methyltransferase 3
  egl-9 family hypoxia inducible factor 3
  endonuclease V
  ER lipid raft associated 2
  family with sequence similarity 86 member B2
  F-box and WD repeat domain containing 8
  F-box protein 6
  folliculin
  FYVE and coiled-coil domain autophagy adaptor 1
  G protein subunit beta 5
  G1 to S phase transition 2
  glucosidase II alpha subunit
  glutamate rich WD repeat containing 1
  glutamine amidotransferase like class 1 domain containing 1
  guanine nucleotide binding protein (G protein), beta 1
  heat shock protein family H (Hsp110) member 1
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 11
  hook microtubule tethering protein 1
  host cell factor C2
  hypoxia inducible factor 1 subunit alpha inhibitor
  integrin alpha FG-GAP repeat containing 1
  kelch domain containing 2
  kelch domain containing 8A
  kelch like family member 33
  kelch like family member 34
  kelch repeat and BTB domain containing 4
  kinase suppressor of ras 1
  kinesin family member 21A
  kinesin family member 21B
  L3MBTL histone methyl-lysine binding protein 2
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat containing 10
  leucine rich repeat kinase 1
  ligand dependent nuclear receptor corepressor
  lysine demethylase 4B
  methylphosphate capping enzyme
  methyltransferase like 14
  methyltransferase like 18
  methyltransferase like 3
  MINDY lysine 48 deubiquitinase 4
  mitogen-activated protein kinase 13
  mitogen-activated protein kinase 15
  MKS transition zone complex subunit 1
  MOB family member 4, phocein
  MTOR associated protein, LST8 homolog
  NEDD1 gamma-tubulin ring complex targeting factor
  neural precursor cell expressed, developmentally down-regulated gene 1
  notchless homolog 1
  NSFL1 cofactor
  obscurin like cytoskeletal adaptor 1
  parkin coregulated
  patatin like phospholipase domain containing 1
  patatin like phospholipase domain containing 5
  phosphatidylinositol 4-kinase type 2 beta
  phosphoethanolamine/phosphocholine phosphatase 1
  phospholipase B1
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  POC1 centriolar protein A
  POC1 centriolar protein B
  polo like kinase 4
  polycomb group ring finger 5
  polycomb group ring finger 6
  pre-mRNA processing factor 40 homolog A
  pre-mRNA processing factor 8
  protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
  protein phosphatase 2 regulatory subunit Bdelta
  protein phosphatase 4, catalytic subunit
  protein phosphatase 6, catalytic subunit
  protein phosphatase, Mg2+/Mn2+ dependent 1J
  RAP2C, member of RAS oncogene family
  receptor interacting serine/threonine kinase 4
  regulatory associated protein of MTOR complex 1
  ring finger and CCCH-type domains 2
  ring finger and WD repeat domain 3
  RIO kinase 1
  SAMM50 sorting and assembly machinery component
  SEC31 homolog B, COPII coat complex component
  sirtuin 7
  SMAD specific E3 ubiquitin protein ligase 1
  small ubiquitin like modifier 4
  SNW domain containing 1
  spermine oxidase
  splicing factor 3b subunit 3
  STE20 related adaptor beta
  striatin 3
  striatin, calmodulin binding protein 3
  SUMO specific peptidase 2
  testis specific serine kinase 6
  tetratricopeptide repeat domain 27
  THO complex 3
  TNFAIP3 interacting protein 2
  transducin beta like 1 Y-linked
  transformed mouse 3T3 cell double minute 2
  tRNA methyltransferase 12 homolog
  tubulin alpha 1c
  tubulin alpha 3e
  tubulin alpha like 3
  tubulin beta 2B class IIb
  tubulin beta class I
  tubulin gamma 2
  tubulin tyrosine ligase like 3
  tubulin tyrosine ligase like 9
  tubulin, alpha 3A
  tubulin, epsilon 1
  tubulin, gamma 1
  U2 small nuclear RNA auxiliary factor 2
  ubiquilin 2
  vir like m6A methyltransferase associated
  VRK serine/threonine kinase 3
  WD and tetratricopeptide repeats 1
  WD repeat containing antisense to TP53
  WD repeat containing, antisense to TP73
  WD repeat domain 37
  WD repeat domain 48
  WD repeat domain 5
  WD repeat domain 5B
  WD repeat domain 61
  WD repeat domain 76
  WD repeat domain 77
  WD repeat domain 83
  WD repeat domain 86
  WD repeat domain 92
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  zinc finger CCCH-type containing 7A
  zinc finger containing ubiquitin peptidase 1
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.