CDC73, cell division cycle 73

CDC73, cell division cycle 73

• This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009]

• Gene Synonyms (parafibromin, Familial isolated hyperparathyroidism, Paf1/RNA polymerase II complex component, cell division cycle 73 Paf1/RNA polymerase II complex component-like protein, cell division cycle 73, Paf1/RNA polymerase II complex component, homolog, cell division cycle protein 73 homolog, hyperparathyroidism 2 protein, C1orf28, FIHP, HPTJT, HRPT1, HRPT2, HYX,)
• NCBI Gene ID: 79577
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6P1J9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cell division cycle 73 interacts with:

• BCL9 like
  centrobin, centriole duplication and spindle assembly protein
  centrosomal protein 70
  chromosome 1 open reading frame 131
  coiled-coil domain containing 88B
  component of oligomeric golgi complex 3
  dermcidin
  erythroblast membrane associated protein (Scianna blood group)
  fibronectin type III and SPRY domain containing 2
  filaggrin family member 2
  G protein-coupled receptor associated sorting protein 2
  golgin A6 family like 9
  histocompatibility minor 13
  integrin alpha FG-GAP repeat containing 1
  KASH domain containing 5
  LEO1 homolog, Paf1/RNA polymerase II complex component
  myosin heavy chain 14
  myosin IIIB
  Nanog homeobox
  POTE ankyrin domain family member E
  RAB1B, member RAS oncogene family
  RAB40A like
  RAB40A, member RAS oncogene family
  RIO kinase 1
  testis specific 10
  TOX high mobility group box family member 4
  tubulin beta 8 class VIII
  ubiquitin like with PHD and ring finger domains 2
  VPS37B subunit of ESCRT-I
  WD repeat domain 61
  zinc finger and BTB domain containing 38
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.