DCD, dermcidin

DCD, dermcidin

• This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

• Gene Synonyms (AIDD, DCD-1, DSEP, HCAP, PIF, dermcidin, diffusible survival/evasion peptide, preproteolysin, proteolysis inducing factor, survival promoting peptide,)
• NCBI Gene ID: 117159
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P81605
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

dermcidin interacts with:

• centrosomal protein 290
  IQ calmodulin-binding motif containing 1
  ring finger and CCCH-type domains 1
  ring finger protein 38
  zinc finger containing ubiquitin peptidase 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.