U2AF2, U2 small nuclear RNA auxiliary factor 2

U2AF2, U2 small nuclear RNA auxiliary factor 2

• U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008]

• Gene Synonyms (splicing factor U2AF 65 kDa subunit, U2 (RNU2) small nuclear RNA auxiliary factor 2, U2 auxiliary factor 65 kDa subunit, U2 small nuclear ribonucleoprotein auxiliary factor (65kD), U2 snRNP auxiliary factor large subunit, hU2AF65, U2AF65,)
• NCBI Gene ID: 11338
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P26368
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

U2 small nuclear RNA auxiliary factor 2 interacts with:

• AAR2 splicing factor
  AHNAK nucleoprotein
  apoptotic chromatin condensation inducer 1
  BEN domain containing 7
  bromodomain containing 7
  cap methyltransferase 1
  CASC3 exon junction complex subunit
  CDV3 homolog
  cell division cycle and apoptosis regulator 1
  ceramide kinase
  cereblon
  chromatin target of PRMT1
  chromodomain helicase DNA binding protein 8
  cleavage and polyadenylation specific factor 7
  coiled-coil-helix-coiled-coil-helix domain containing 10
  cullin associated and neddylation dissociated 1
  cysteine rich hydrophobic domain 2
  developmental pluripotency associated 2
  developmental pluripotency-associated 3
  DNA polymerase delta interacting protein 3
  Enah/Vasp-like
  extended synaptotagmin 1
  family with sequence similarity 107 member B
  GLIS family zinc finger 2
  glucosidase II alpha subunit
  G-patch domain containing 11
  G-patch domain containing 8
  GRB10 interacting GYF protein 2
  H2A.J histone
  heterogeneous nuclear ribonucleoprotein A3
  homeobox containing 1
  INO80 complex subunit B
  integrin alpha FG-GAP repeat containing 1
  jumonji domain containing 6, arginine demethylase and lysine hydroxylase
  Jupiter microtubule associated homolog 2
  KH domain containing 4, pre-mRNA splicing factor
  La ribonucleoprotein 1, translational regulator
  leucine aminopeptidase 3
  leucine rich adaptor protein 1
  leucine rich repeat containing 59
  LUC7 like
  LUC7 like 2, pre-mRNA splicing factor
  methyltransferase like 14
  methyltransferase like 3
  microtubule associated protein RP/EB family member 1
  mitochondrial ribosomal protein L15
  mitochondrial ribosomal protein S9
  NKAP domain containing 1
  nuclear receptor coactivator 5
  nucleolar and spindle associated protein 1
  obscurin like cytoskeletal adaptor 1
  OTU deubiquitinase, ubiquitin aldehyde binding 2
  paraspeckle component 1
  PHD finger protein 5A
  phosphoglycerate dehydrogenase
  pleckstrin homology domain containing A4
  POC1 centriolar protein A
  poly(A) binding protein cytoplasmic 1
  poly(U) binding splicing factor 60
  pre-mRNA processing factor 19
  pre-mRNA processing factor 40 homolog A
  pre-mRNA processing factor 6
  protein phosphatase 2, regulatory subunit B', gamma
  RALY heterogeneous nuclear ribonucleoprotein
  ribosomal RNA processing 7 homolog A
  ribosome biogenesis regulator 1 homolog
  ribosome production factor 2 homolog
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  RNA binding fox-1 homolog 2
  RNA binding motif protein 11
  RNA binding motif protein X-linked
  RNA binding motif protein Y-linked family 1 member F
  RNA binding motif protein Y-linked family 1 member J
  SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
  SAP domain containing ribonucleoprotein
  SAP30 binding protein
  serine and arginine rich splicing factor 12
  serine/arginine repetitive matrix 2
  SERPINE1 mRNA binding protein 1
  SH3 and cysteine rich domain 3
  SH3 domain containing ring finger 2
  sirtuin 7
  small nuclear ribonucleoprotein U5 subunit 200
  SNW domain containing 1
  splicing factor 3b subunit 1
  splicing factor 3b subunit 3
  splicing factor 3b subunit 5
  splicing factor 3b subunit 6
  SRA stem-loop interacting RNA binding protein
  SR-related CTD associated factor 1
  staphylococcal nuclease and tudor domain containing 1
  SURP and G-patch domain containing 1
  SUZ12 polycomb repressive complex 2 subunit
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  TAR DNA binding protein
  THAP domain containing 1
  THO complex 6
  transcription factor 23
  transformer 2 alpha homolog
  tubulin beta class I
  U2 small nuclear RNA auxiliary factor 1 like 5
  U2 small nuclear RNA auxiliary factor 2
  U2 snRNP associated SURP domain containing
  vir like m6A methyltransferase associated
  zinc finger CCCH-type containing 13
  zinc finger CCCH-type containing 18
  zinc finger CCHC-type containing 3
  zinc finger CCHC-type containing 8
  zinc finger protein 107
  zinc finger protein 526
  zinc finger protein 57
  zinc finger protein 71
  zinc finger protein 835

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.