CHD8, chromodomain helicase DNA binding protein 8

CHD8, chromodomain helicase DNA binding protein 8

• This gene encodes a member of the chromodomain-helicase-DNA binding protein family, which is characterized by a SNF2-like domain and two chromatin organization modifier domains. The encoded protein also contains brahma and kismet domains, which are common to the subfamily of chromodomain-helicase-DNA binding proteins to which this protein belongs. This gene has been shown to function in several processes that include transcriptional regulation, epigenetic remodeling, promotion of cell proliferation, and regulation of RNA synthesis. Allelic variants of this gene are associated with autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016]

• Gene Synonyms (AUTS18, HELSNF1, chromodomain-helicase-DNA-binding protein 8, ATP-dependent helicase CHD8, axis duplication inhibitor, duplin, helicase with SNF2 domain 1,)
• NCBI Gene ID: 57680
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9HCK8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

chromodomain helicase DNA binding protein 8 interacts with:

• aldehyde dehydrogenase 1 family member L2
  egl-9 family hypoxia inducible factor 3
  F-box protein 38
  general transcription factor IIB
  IKAROS family zinc finger 5
  nuclear factor of activated T cells 2 interacting protein
  protocadherin 20
  ret finger protein like 4B
  synaptosomal-associated protein 29
  transducin beta like 1 Y-linked
  ubiquitin like with PHD and ring finger domains 2
  ubiquitin specific peptidase 37
  X antigen family member 1A
  zinc finger protein 707

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.