TARDBP, TAR DNA binding protein

TARDBP, TAR DNA binding protein

• HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]

• Gene Synonyms (TAR DNA-binding protein 43, TAR DNA-binding protein-43, ALS10, TDP-43,)
• NCBI Gene ID: 23435
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9H256
  UNIPROT ID#>>Q13148
  UNIPROT ID#>>A0A024R4E2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TAR DNA binding protein interacts with:

• 5'-3' exoribonuclease 1
  actin beta like 2
  AHNAK nucleoprotein
  argonaute RISC catalytic component 2
  autophagy related 16 like 1
  cell cycle and apoptosis regulator 2
  centrosomal protein 290
  charged multivesicular body protein 2A
  cleavage and polyadenylation specific factor 1
  CTD small phosphatase like 2
  cullin associated and neddylation dissociated 1
  DEAH-box helicase 36
  dermcidin
  DExD-box helicase 50
  DExH-box helicase 57
  DIMT1 rRNA methyltransferase and ribosome maturation factor
  ER membrane protein complex subunit 6
  family with sequence similarity 98 member A
  F-box protein 6
  F-box protein 7
  G protein nucleolar 3
  glutaminyl-peptide cyclotransferase like
  GRB10 interacting GYF protein 2
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein F
  heterogeneous nuclear ribonucleoprotein U like 2
  inositol hexakisphosphate kinase 3
  KH RNA binding domain containing, signal transduction associated 2
  kinesin family member 4B
  La ribonucleoprotein 4
  leucine rich repeat containing 15
  LSM12 homolog
  LUC7 like 2, pre-mRNA splicing factor
  metadherin
  methyltransferase like 14
  methyltransferase like 3
  mitochondrial ribosomal protein L22
  mitochondrial ribosomal protein L44
  mitochondrial ribosomal protein L48
  mitochondrial ribosomal protein S22
  mitochondrial ribosomal protein S34
  Mtr4 exosome RNA helicase
  musashi RNA binding protein 2
  NDRG family member 3
  NFKB repressing factor
  NOP16 nucleolar protein
  NOP58 ribonucleoprotein
  NSFL1 cofactor
  nuclear FMR1 interacting protein 2
  nucleus accumbens associated 1
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  parkin RBR E3 ubiquitin protein ligase
  PAT1 homolog 1, processing body mRNA decay factor
  phosphoglycerate dehydrogenase
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 1
  pre-mRNA processing factor 19
  PYM homolog 1, exon junction complex associated factor
  Rac GTPase-activating protein 1
  Rho guanine nucleotide exchange factor 28
  ribosomal protein L13a
  ring finger and CCCH-type domains 2
  RNA binding motif protein 45
  RNA binding motif protein X-linked
  S1 RNA binding domain 1
  SDA1 domain containing 1
  SERPINE1 mRNA binding protein 1
  serrate, RNA effector molecule
  solute carrier family 25 member 23
  splicing factor 3b subunit 1
  SRP receptor subunit beta
  staphylococcal nuclease and tudor domain containing 1
  TAR DNA binding protein
  testis expressed 101
  tRNA methyltransferase 1 like
  TSR1 ribosome maturation factor
  tubulin alpha 1c
  tubulin alpha 8
  tubulin beta class I
  ubiquilin 1
  ubiquilin 2
  vir like m6A methyltransferase associated
  WW domain containing oxidoreductase
  YTH domain containing 2
  YTH N6-methyladenosine RNA binding protein 2
  zinc finger AN1-type containing 2B
  zinc finger CCCH-type containing, antiviral 1
  zinc finger protein 346
  zinc finger protein 746
  zinc finger RNA binding protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.