CPSF1, cleavage and polyadenylation specific factor 1

CPSF1, cleavage and polyadenylation specific factor 1

• Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]

• Gene Synonyms (cleavage and polyadenylation specificity factor subunit 1, CPSF 160 kDa subunit, cleavage and polyadenylation specific factor 1, 160kDa, cleavage and polyadenylation specificity factor 160 kDa subunit, polyadenylation specificity factor, CPSF160, HSU37012, MYP27, P/cl.18,)
• NCBI Gene ID: 29894
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q10570
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cleavage and polyadenylation specific factor 1 interacts with:

• cell division cycle 73
  cleavage and polyadenylation specific factor 1
  cleavage and polyadenylation specific factor 2
  cleavage and polyadenylation specific factor 3
  factor interacting with PAPOLA and CPSF1
  F-box and WD repeat domain containing 7
  GLIS family zinc finger 2
  inhibitor of CDK, cyclin A1 interacting protein 1
  leucine rich repeat containing G protein-coupled receptor 4
  mediator complex subunit 8
  pleckstrin homology domain containing A4
  potassium channel modulatory factor 1
  RAD18 E3 ubiquitin protein ligase
  ring finger protein 123
  RNA binding region (RNP1, RRM) containing 3
  S-adenosylhomocysteine hydrolase-like 1
  sirtuin 7
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  terminal uridylyl transferase 1, U6 snRNA-specific
  TNFAIP3 interacting protein 2
  WD repeat domain 33
  WW domain containing oxidoreductase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.